因此,CD56neg NK 细胞群的增多反映了病毒颠覆 NK 细胞应答的机制。 信源:Müller-Durovic B, Grählert J, Devine OP, Akbar AN, Hess C. CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age. ...
为了明确肿瘤微环境对NK细胞的影响,我们将来自健康人的外周血单个核细胞(peripheral blood mononuclear cells, PBMCs)与癌、癌旁和血管瘤组织的组织匀浆共培养了一段时间后进行流式细胞术分析。结果发现,与肿瘤组织匀浆共培养的细胞中N...
NK cells lacking CD56 (CD56neg) were first identified in chronic HIV‐1 infection. However, CD56neg NK cells also exist in healthy individuals, albeit in significantly lower numbers. Here, we provide an extensive proteomic characterisation of human CD56neg peripheral blood NK cells of healthy ...
Natural killer cells lacking expression of CD56 (CD56neg NK cells) have been described in chronic HIV and hepatitis C virus infection. Features and functions of CD56neg NK cells in the context of latent infection with CMV and / or EBV with age are not known. In a cohort of healthy donor...
6. The cells were resuspended in 1/2 volume of precooling 10% glycerol, 4000r / min at 4 ℃ for 20min, the supernatant was discarded.7. Repeat step (6).8. Resuspend the cells in 15 ml of 10% glycerol and transfer to a 50 ml centrifuge tube. Centrifuge at 3500 r / min for 15...
该研究是非常典型的lncRNA研究思路,其中的lncRNA生物学功能挖掘和表达网络分析也是非常实用的lncRNA功能挖掘思路,非常值得借鉴。 原文出处 Zhang R, Ni F, Fu B, et al. A long noncoding RNA positively regulates CD56 in human natural killer cells.Oncotarget.2016....
Marker of NK cells and NK lymphomas Detect residual myeloma (Am J Clin Pathol 2009;132:60) and residual AML in bone marrow (Am J Clin Pathol 2008;129:934) Differentiate plasma cells in myeloma (CD56+) from reactive plasmacytosis or MGUS (CD56-, Am J Pathol 2002;160:1293, Am J Cl...
in expanding populations of NK cells, EL08.1D2 are most efficient in their ability to significantly induce terminal maturation5. Further, their effectiveness requires direct contact with EL08.1D2 cells5. The contact-dependent factors that make these cells uniquely able to support this terminal stage...
During the progression of HIV-1 infection, the down-regulation of PD-1 has a positive effect on restoring the CD4+ T cells pool.17 Natural killer cells (NK cells), as innate immune lymphocytes, play an important role in eliminating virus-infected cells. According to the level of membrane ...
该研究是非常典型的lncRNA研究思路,其中的lncRNA生物学功能挖掘和表达网络分析也是非常实用的lncRNA功能挖掘思路,非常值得借鉴。 原文出处 Zhang R, Ni F, Fu B, et al. A long noncoding RNA positively regulates CD56 in human natural killer cells.Oncotarget.2016....