•表达低水平的CD57和KIR•T-bet表达降低但Eomes表达正常•未见细胞衰老特征•PD-1和TIM-3等抑制性受体表达未升高 以上种种证据,提示CD56neg NK细胞可能是评估老年人免疫风险的新型标志物。 参考文献:Müller-Durovic B, Grählert J, Devine OP, Ak...
因此,CD56neg NK 细胞群的增多反映了病毒颠覆 NK 细胞应答的机制。 信源:Müller-Durovic B, Grählert J, Devine OP, Akbar AN, Hess C. CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age. ...
•表达低水平的CD57和KIR•T-bet表达降低但Eomes表达正常•未见细胞衰老特征•PD-1和TIM-3等抑制性受体表达未升高 以上种种证据,提示CD56neg NK细胞可能是评估老年人免疫风险的新型标志物。 参考文献:Müller-Durovic B, Grählert J, Devine OP, Akbar AN, Hess C. CD56-negative NK cells with impa...
•表达低水平的CD57和KIR•T-bet表达降低但Eomes表达正常•未见细胞衰老特征•PD-1和TIM-3等抑制性受体表达未升高 以上种种证据,提示CD56neg NK细胞可能是评估老年人免疫风险的新型标志物。 参考文献:Müller-Durovic B, Grählert J, Devine OP, Akbar AN, Hess C. CD56-negative NK cells with impa...
also contains an antibody to human Fc receptor to minimize nonspecific binding. Labeled cells are separated using an EasySep™ magnet without the use of columns. Cells of interest remain in the tube while unwanted cells are poured off. The CD56 antigen is expressed on NK cells and NKT cells...
5. The culture was placed in an ice bath 15min, then 4000r / min at 4 ℃ for 20min, the supernatant was discarded.6. The cells were resuspended in 1/2 volume of precooling 10% glycerol, 4000r / min at 4 ℃ for 20min, the supernatant was discarded.7. Repeat step (6).8. ...
Marker of NK cells and NK lymphomas Detect residual myeloma (Am J Clin Pathol 2009;132:60) and residual AML in bone marrow (Am J Clin Pathol 2008;129:934) Differentiate plasma cells in myeloma (CD56+) from reactive plasmacytosis or MGUS (CD56-, Am J Pathol 2002;160:1293, Am J Cl...
CD56neg NK cells had a mature phenotype characterized by low CD57 and KIR expression and lacked characteristics of cell senescence. No changes in their activating NK cell receptor expression, and no upregulation of the negative co-stimulation receptors PD-1 or TIM-3 were observed. In all, ou...
Natural killer (NK) cells play a key role in the innate immune system. These lymphocytes react to certain infections and malignancies by direct cytolysis of infected or transformed cells and by secretion of potent immune mediators. NK cells have the ability to recognize foreign or stressed cells...
In this study, the analysis of CD56 bright and CD56 dim NK subsets showed that neither the number nor the phenotype of CD56 bright NK cells were significantly altered in treatment-naive HIV-1-infected individuals, whereas the number of CD56 dim NK cells was decreased. We also have studied ...