doi:10.1038/s41392-023-01494-5Schwarz, SandraLinnebacher, MichaelNature Publishing Group UKSignal Transduction & Targeted Therapy
CD5 is a pan T cell marker also expressed at various developmental and activation stages on human B cells. CD5 is a well established negative regulator of TCR and BCR signalling. In the last years, great advances have been made in understanding the molecular mechanisms behind this regulatory ...
Chimeric antigen receptor engineered T cells (CAR-T) have demonstrated promising clinical efficacy in B-cell malignancies, and the approach has been extended to T-cell malignancies. However, the use of allogeneic T cells in CAR therapy poses a challenge due to the risk of graft-versus-host dis...
Although CD5 can be found on both T cells and B cells, T cells express higher levels of CD5 than B cells. CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed. CD5 is upregulated on T cells upon strong activation. In the thymus, there is a ...
This Antibody recognizes a 67 kDa transmembrane protein,which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes,the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts ...
By another way, it has been found that the CD5 T cell antigen is also present on a minor subpopulation of B cells in the spleen but not in the blood [14]. We suggest that in the bovine a similar B cell subpopulation should be the BLV target and expand as a consequence of viral ...
Bovine leukemia virus (BLV)-infected B-cells express a marker similar to the CD5 T cell marker Immunology Letters Volume 20, Issue 1, 15 January 1989, Pages 69-76 Purchase options CorporateFor R&D professionals working in corporate organizations. Academic and personalFor academic or personal use...
CD5(套细胞淋巴瘤标记)抗体,克隆CD5 / 54 / F6(浓缩液),CD5 (Mantle Cell Lymphoma Marker); Clone CD5/54/F6 (Concentrate) 其他 ScyTek公司始建于1991年,以成为世界级生命科学研究试剂生产商为目标。ScyTek从创立之初就采取了严格的原材料筛选程序,生产多种优质试剂,不断应用于各种学科,包括免疫学,组织学...
CD5 is a pan-T cell surface marker that is also present on a subset of B cells, B-1a cells.Functional and developmental subsets of T cells express characteristic CD5 levels that vary over roughly a 30-fold range. Previous investigators have cloned a 1.7 Kb fragment containing the CD5 pro...
Synonyms : T-cell surface glycoprotein CD5, CD5, LEU1, T1 Application : Positive Control, Immunogen, SDS-PAGE, WB Expression host : Baculovirus-Insect Cells Species : Human Datasheet Validation Citation Gene ID 921 Swiss Prot P06127 Synonyms T-cell surface glycoprotein CD5, CD5,...