CD5+ MCL是一种表达CD5的侵袭性B细胞恶性肿瘤,其预后差,中位总生存期(OS)为3~5年。然而,部分MCL患者起病缓慢,多表现为惰性,其生存时间超过10年,非结节病变、SOX11表达缺乏及IGHV超突变多出现在这些患者中。这种预后更好的MCL患者具有独特的免...
Marginal zone lymphomaObjectives: The importance of distinguishing mature B-cell lymphoproliferative disorders (B-LPDs) is highlighted by the distinct treatments used for and varying prognoses seen in association with these different diseases. Immunophenotyping allows for accurate and efficient differentiation ...
Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression SOX11 expression has been recently shown to be useful in the diagnosis of mantle cell lymphoma (MCL), including cyclin D1-negative MCL with typical morphol... W Zeng,K Fu,L Quintanilla-Fend,... - 《American Jour...
CD10CD5central nervous system lymphomadiffuse large Bヽell lymphomastarry skyThis case highlights the need for both tissue biopsy for diagnosis in suspected CNS malignancy and comprehensive immune profiling for accurate subclassification.doi:10.1002/ccr3.3293Colin McCorkle...
Harada,Suzuki R,Uehira K, et al.Molecular and immunological dissection of diffuse large B-cell lymphoma: CD5+, and CD5-with CD10+ groups may constitute clinically relevant subtypes. Leukemia . 1999Harada, S., Suzuki, R., Uehira, K. et al. 1999. Molecular and immunologi- cal ...
Typically, the neoplastic MALT lymphoma cells coexpress CD20+ and surface light-chain restriction but are negative for CD10 and CD5. Some researchers have documented expression of CD5 in MALT lymphomas, which is rare. Aberrant CD5-expression is thought to be a marker of early dissemination and...
CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung is very rare. An 82-year-old Japanese woman was found to have an abnormal lung shadow on chest X-ray photography, and was admitted to our hospital. Imaging modalities including X-ray pho...
Her hematogones expressed the T-cell marker CD5 as well as CD19, CD10, and CD20, and terminal deoxynucleotidyl transferase and HLA-DR. These findings suggest that hematogones are precursors of both CD5-positive B cells and CD5-negative B cells. Thus CD5-positive B cells in bone marrow ...
Introduction: There are various poor prognosis factors in diffuse large B cell lymphoma (DLBCL). CD5 positive (CD5+) is estimated as one of the poor prognosis markers in DLBCL. CD5+ DLBCL is completely distinguished from CLL or Mantle cell lymphoma, and de Novo CD5+ DLBCL is related to...
Small lymphocytic lymphoma The typical cases have faint surface IgM/IgD expression with k/l light chain restriction; pan-B antigens are positive, but CD22 expression is weak. CD5 and CD23 test positive, whereas CD10 and FMC7 are negative; the expression of CD11c a... A Cuneo,G Castoldi...