CD5+ MCL是一种表达CD5的侵袭性B细胞恶性肿瘤,其预后差,中位总生存期(OS)为3~5年。然而,部分MCL患者起病缓慢,多表现为惰性,其生存时间超过10年,非结节病变、SOX11表达缺乏及IGHV超突变多出现在这些患者中。这种预后更好的MCL患者具有独特的免...
Lymphoplasmacytic lymphomaMarginal zone lymphomaObjectives: The importance of distinguishing mature B-cell lymphoproliferative disorders (B-LPDs) is highlighted by the distinct treatments used for and varying prognoses seen in association with these different diseases. Immunophenotyping allows for accurate and...
Mantle cell lymphoma (MCL) is a mature B-cell lymphoma characterized by expression of CD5, overexpression of Cyclin D1 as a result of chromosomal translocation t(11;14)(q13;q32), and poor prognosis. Cases of MCL lacking CD5 expression as well as cases with coexpression of CD5 and CD1...
The presence of CCND1 gene rearrangements or cyclin D1 abnormalities should be assessed in such cases to establish the diagnosis of mantle cell lymphoma and exclude other CD5−/CD10− mature B-cell neoplasms. MCL patients are predominantly male (ratio of 2 : 1 or greater) and have ...
Harada,Suzuki R,Uehira K, et al.Molecular and immunological dissection of diffuse large B-cell lymphoma: CD5+, and CD5-with CD10+ groups may constitute clinically relevant subtypes. Leukemia . 1999Harada S, Suzuki R, Uehira K, et al. Molecular and immunological dissection of diffuse large...
CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung is very rare. An 82-year-old Japanese woman was found to have an abnormal lung shadow on chest X-ray photography, and was admitted to our hospital. Imaging modalities including X-ray pho...
Mucosa-associated lymphoid tissue (MALT) lymphoma manifesting as multiple lymphomatosis polyposis of the gastrointestinal tract Flow cytometry revealed CD25 positive/CD5 negative lymphoid cells confirming marginal B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type. Upper... NP Breslin,SJ ...
The gated cells were positive for CD25, CD11c, CD20, and CD103, while CD10 proved to be dim to negative. Moreover, cells positive for CD3, CD4, and CD8, the three pan-T markers, as well as CD19, showed a bright expression of CD5. The atypical CD5 expression is usually correlated...
Ocular mantle cell lymphoma with aberrant CD10 expression: A potential diagnostic pitfall 2009, Pathology Cutaneous manifestations of mantle cell lymphoma: An extensive literature review 2020, Acta Dermatovenerologica Alpina, Pannonica et Adriatica CD5-negative mantle cell lymphoma shows a less aggressive...
Typically, the neoplastic MALT lymphoma cells coexpress CD20+ and surface light-chain restriction but are negative for CD10 and CD5. Some researchers have documented expression of CD5 in MALT lymphomas, which is rare. Aberrant CD5-expression is thought to be a marker of early dissemination and...