没关系,还有其它选择,结合CD45RA/RO能精确定义表型不同的T细胞亚群。在这些标记物中,促进T细胞存活的TNF受体家族成员CD27、介导LN归巢的趋化因子受体CCR7和T细胞活化及存活所需的共刺激分子CD28 都是非常好的标记。而且这几个抗体的荧光素可选范围大,所以在多色方案中...
研究发现,外周血CD45RA+HLA-DR+CD8+T细胞≥9.4%的患者1年内死亡率显著高于CD45RA+HLA-DR+CD8+T细胞<9.4%的患者;外周血CD56dimNK细胞≥0.94%的患者1年内死亡率显著低于CD56dimNK细胞<0.94%的患者(图5C-D)。 我们用流式细胞...
(2006). Increase of CCR7- CD45RA+CD8 T cells (T(EMRA)) in chronic graft-versus-host disease . Leukemia 20 :545–547D’Asaro M,Dieli F,Caccamo N,Musso M,Porretto F,Salerno A.Increase of CCR7- CD45RA+ CD8 T cells (T(EMRA)) in chronic graft-versus-host disease. Leukemia : ...
Preferential Cell Death of CD8+ Effector Memory (CCR7CD45RA) T Cells by Hydrogen Peroxide-Induced Oxidative Stress 1 R. Norell et al., "Preferential cell death of CD8+ effector memory (CCR7-CD45RA-) T cells by hydrogen peroxide-induced oxidative stress," The ... A Takahashi,MGV Hanson,...
Salerno, Increase of CCR7- CD45RA+ CD8 T cells (T(EMRA)) in chronic graft-versus-host disease. Leukemia, 2006. 20(3): p. 545-7.D'Asaro M, ... D'Asaro,Dieli,Caccamo,... - 《Leukemia》 被引量: 78发表: 2006年 Increase of CCR7 CD45RA+ CD8 T cells (TEMRA) in chronic graft...
29 These CMV-specific cytotoxic T cells also express CD57 and lack CCR7 and l-selectin.29, 30, 31 To elucidate the basis for the CD8+ T-cell expansion in B-CLL we investigated the composition of the T-cell compartment in patients with B-CLL via extensive immunophenotypic analysis. In ...
we demonstrated that gastric tumor-derived TNF-αefficiently induced CD45RA−CCR7−Treg subset and inhibited HLA-DR expression on these cells by inducing signal transducer and activator of transcription 3 (STAT3) phosphorylation. In turn, this CD45RA−CCR7−Treg subset suppresses CD8+T-cell ...
we demonstrated that gastric tumor-derived TNF-αefficiently induced CD45RA−CCR7−Treg subset and inhibited HLA-DR expression on these cells by inducing signal transducer and activator of transcription 3 (STAT3) phosphorylation. In turn, this CD45RA−CCR7−Treg subset suppresses CD8+T-cell ...
结核患者抗原特异性CD8+记忆T细胞的检测分析 细胞(peripheral blood mononuclear cells,PBMCs),以结核分枝杆菌抗原ESAT-6刺激,通过CD8,CD107a,CCR7,CD45RA抗体共染色,采用流式细胞术分析.结果 建立了基于CD... 蒋静,王仙园,邓少丽,... - 《第三军医大学学报》 被引量: 10发表: 2011年 周围血中CD3+TCRvα...
Isolated EBV-specific CD8+ T cells that were CD45RO+ could be induced to re-express CD45RA by incubation with IL-15, and these cells exhibited potent cytotoxic activity against EBV infected target cells [9]. Furthermore, IL-15 injections can induce massive expansions of CCR7−CD28−CD8+...