Access : CD45RA T-cell activation without proliferation by a partial agonist monoclonal antibody to --[beta]--1 integrin : Immunology and Cell Biology. Immunology and cell biology, 86(4):381-4, Jan. 2008. ISSN 0818-9641. doi: 10.1038/sj.icb.7100165. URL http...
基于以上的结论,为了进一步求证CD45的分离对于FcϒR磷酸化和吞噬作用是否是必须的,研究者们使用CRISPR/Cas9截短了内源性的CD45胞外段进行实验,发现截短的CD45使短抗原介导的吞噬作用显著降低了。 综上,结论如下:抗原大小很大程度上决定了抗体依赖的吞噬作用是否成功,而这个吞噬作用又是通过大小依赖的CD45分离导致...
近日宾夕法尼亚大学医学院的研究人员揭示了CD45形成不同的异型的调控机制。研究论文发表在本月的《分子细胞》(Molecular Cell)杂志上。 在T淋巴细胞中,不同的细胞亚群活化过程中CD45的表达也可发生变化。CD45分子不同异型的转换有助于T细胞正确地发挥功能,并在防止自身免疫系统攻击中发挥重要作用。因此了解CD45异型...
We have previously identified human cardiac C-kit+CD45− cells, but only found evidence of endothelial commitment. A small cardiac committed subpopulation within the C-kit+CD45− population might however be present. To investigate this at single-cell level, right and left atrial biopsies were...
CD34+/CD45- stem cells from diverse lineages and their applicability for cell therapy 来自 Semantic Scholar 喜欢 0 阅读量: 21 作者: B Bose 摘要: From the perspective of cell therapy and understanding the basic biology of adult stem cells residing in tissues of thedifferent germline origin, we...
cell is said to be “CD45 positive” if an isoform of the CD45 antigen is present on its surface; the cell is said to be “CD45 negative” if no isoforms of CD45 are detected on its surface. In this way, the expression of CD45 is commonly used as a “white blood cell marker....
Unexpectedly, equivalent responses were found among the CD4+CD45RA+ and CD4+CD45RO+ populations of T cells. This response requires MHC class II-positive antigen-presenting cells. The time course of the T cell response in vitro was that of a classical recall response, and no proliferative ...
Lin-/Sca-1+/CD45−cells (VSELs) and Lin−/Sca-1+/CD45+cells (HSCs) were isolated from the BM of adult C57BL/6 mice (five weeks old; Jackson Laboratory, USA). Bone marrow was flushed from the cavities of tibias and femurs, and the cell suspension was collected and filtered thro...
上海玉博生物科技有限公司 主要致力于“Human CD45+ Hematopoietic Cells PlusCellect R&D-PLS1430”的生产销售。多年的“Human CD45+ Hematopoietic Cells PlusCellect R&D-PLS1430”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我公司经营的产品名称深受广
Background: The developmental origin of the c-kit expressing progenitor cell pool in the adult heart has remained elusive. Recently, it has been discovered that the injured heart is enriched with c-kit cells, which also express the hematopoietic marker CD45. 关键词: Adult stem cells Macrophages...