显示CD45-PET能够可靠地检测IBD模型中的肠道炎症,探针的摄取与免疫浸润的解剖学和组织学证据高度相关,CD45-PET信号反映了疾病严重度的多个参数,优于18F-FDG-PET。 图4展示了CD45-PET在IBD模型中监测治疗反应的能力,表明CD45-PET能够通过连续成像监测IBD模型中小鼠对治疗...
为了解决这个问题,近日,来自哈佛医学院的Mohammad Rashidian团队在Nature上发表了文章CD45-PET is a robust, non-invasive tool for imaging inflammation,开发了基于白细胞共同抗原CD45的PET探针,由纳米抗体(nanobody)、C端特异性标记PEG...
CD45-PET成像具有显著的临床应用前景,它能够通过对个体患者的炎症特征进行精准的全身评估,为炎症性疾病的诊断和治疗决策提供有力的工具。 文章来源: Salehi Farid, Ali, Rowley, Jennifer E. et al, CD45-PET is a robust, non-invasive tool for imaging inflammation. DOI: 10.1038/s41586-024-08441-6, Na...
The lack of a specific and sensitive positron emission tomography (PET) probe to detect inflammation is a critical challenge. To bridge this gap, we present CD45-PET imaging, which detects inflammation with exceptional sensitivity and clarity in several preclinical models. Notably, the intensity of...
CD45是一种在所有免疫细胞上大量表达但在其他细胞类型中不存在的标志物。研究团队开发的CD45-PET探针能够通过PET成像技术,清晰显示体内富含免疫细胞的器官和炎症区域。相关研究成果发表在《Nature》期刊上,题为“CD45-PET is a robust, non-invasive tool for imaging inflammation”。
Publisher’s noteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Extended data figures and tables Extended Data Fig. 1 CD45-PET probe is highly specific to CD45. a,b,Representative PET/CT (left) and PET (right) images of(a...
相反,其他PET探针因只能检测少数免疫过程和疾病的特定靶点,可能导致假阴性结果。因此,迫切需要开发一种在诊断和监测炎症状态时能兼顾灵敏度和特异性的PET探针。 为了解决这个问题,近日,来自哈佛医学院的Mohammad Rashidian团队在Nature上发表了文章CD45-PET is a robust, non-invasive tool for imaging inflammation开发...
The present invention provides a composition preferably a pet foodstuff comprising pantothenic acid, nicotinamide, histidine, inositol and choline wherein pantothenic acid is provided at a level of 10 mg to 500 mg per 400 kcal per day, i... Timothy R. Fray,Peter J. Markwell,Adrian L. Watson...
33 In brief, purified HLA-A2.1 or HLA-B7 heavy chain and β2-microglobulin were synthesized using a prokaryotic expression system (pET; Novagen, Milwaukee, WI). The heavy chain was modified by deletion of the transmembrane/cytosolic tail and C-terminal addition of a sequence containing the ...
RBF Tepet 被引量: 0发表: 2012年 自然宗教与启示宗教之类比 : The analogy of religion, natural and revealed to the constitution and course of nature This article has no associated abstract. ( fix it ) 巴特勒闻骏 - 自然宗教与启示宗教之类比 : The analogy of religion, natural and revealed to...