CD52)、HuM195(抗CD33)等在恶性血液病治疗中巨 大成功的影响,多种新型单抗类药物正处于开发和研 究中口]。CD45分子广泛表达于各种造血细胞表面,是 恶性血液系统疾病靶向治疗的理想抗原,现将近年抗 CD45单抗在恶性血液病治疗中的研究进展作一综述。 1 CD45分子及其单克隆抗体制备 CD45分子又称白细胞共同抗原,属...
HLA-DR表达阴性¨。 本研究中,因其他抗大鼠抗体不易获得,而抗大鼠CD45,CD90较易获得,故应 用此两种抗体鉴定密度梯度离心法与贴壁法相结合所得细胞中骨髓间充质干细胞 的纯度。3次独立实验结果平均纯度为42.15%。此结果进一步证实密度梯度离心 法与贴壁法相结合可成功分离出骨髓间充质干细胞,但鉴定结果与预期结果...
aSurface expression of CD33 versus CD11b on CD45+gated cells from the peripheral blood of GC patients or healthy donors as analyzed by flow cytometry.bCorrelation between the percentages of peripheral blood CD45+CD33lowCD11bdimmyeloid cell and IFN-γ-producing CD8+T cells in GC patients.cNeutr...
(J5), CD13 (MY7), CD14 (MY4 and Leu-M3), CD15 (MY1), CD19 (Leu-12), CD20 (Leu-16), CD21 (anti-CR2), CD22 (Leu-14), CD33 (MY9), CD34 (HPCA-1/ MY10), CD36 (5F1), CD41 (α-gpIIb/IIIa), CD45 (HLe-l/2Dl), CD71 (antitransferrin receptor), and anti-HLA-DR...
The accumulated clinical experience shows the feasibility of integrating radioimmunoconjugates targeting CD33, CD45, or CD66 antigens into treatment regimens for leukemias.51 Our group has focused on the CD45 antigen as an attractive alternative target for radioimmunotherapy of AML and MDS. This ...
MPB- and CML-enriched CD34 þ cells were gated on the LinÀCD34 þ CD38ÀCD90 þ CD45RAÀ sub-population (as demonstrated in Figure 1) and analyzed for their expression of HLA-DR, c-kitR, Tie2, CD69, CD33 and the IL-3R by flow cytometry using Alexa Fluor 700-conjugated ...
Based on the safety of this approach as detailed in this report, we are also conducting a clinical trial in which131I-BC8 antibody is combined with busulfan and CY for patients with AML in first remission receiving HLA-matched transplants.58 Ninety percent of patients have had favorable ...