在分析TH和TC淋巴细胞中的CD44和CD62L时,我们可以区分出三个不同的亚群:CD62LhiCD44neg/lo初始T、CD62LhiCD44hi中央记忆(CM)细胞和CD62Lneg/loCD44hi效应记忆(EM)细胞。 欢迎转发到朋友圈,但谢绝复制粘贴转载 Promotions below
CD62L is a 74-95 kD glycoprotein,also known as L-selectin, LECAM-1, Ly-22 and MEL-14.It is a member of the selectin family and is expressed on the majority of B and naïve T cells,a subset of memory T cells,granulocytes ,subsets of thymocytes and NK cells.CD62L is important ...
Besides, RES decreased the number of CD4+ T cells in peripheral blood, decreased the expression of CD25 and CD44, but not affected the expression of L-selectin (CD62L). In vitro, RES decreased the expression of Ki67, CD25 and ... L Zhou,J Long,Y Sun,... - BioMed Central 被引量:...
NK Cells Regulate CD62L − CD44 − T Cell Subset in the Development of Pathogenic T Cells in a Murine Model of Colitisgastric cancermolecular biomarkerprognostic factorGLOIdoi:10.1016/S0016-5085(11)62016-7Osamu YamajiTeruji TotsukaTakashi Nagaishi...
CD4 T细胞亚群的标记基因包括: 1. CD4:所有CD4 T细胞都会表达CD4分子。 2. CD45RA:通常与CD45RO一起使用,用于区分记忆T细胞。 3. CD27:标记年轻T细胞。 4. CD28:一些T细胞表达CD28,尤其是初始T细胞。 5. CCR7:用于标记中央记忆T细胞和效应记忆T细胞。 6. CD127:用于标记具有高增殖能力的T细胞。 7. CD62L...
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. IL-17-producing CD8+ T (Tcl7) cells are detectible in multiple sclerosis (MS) lesions; however, their contri-bution to the disease is unknown. To identify ... Huber,Magdalena - 《Journal of Clinical Investi...
by the adoptive transfer of lamina propria (LP) colitogenic effector memory CD4+ T cells (TEM cells; CD45RB(low)CD44(high)CD62L-) into severe combined immunodeficiency (SCID) mice and suppresses interferon-gamma, interleukin-2, and tumor necrosis factor-alpha production by LP CD4+ T cells....
Objective CD44HighCD62L- is the marker for effector memory T cell. It is well-known that CD4+ T memory cells (Tms) play important role in asthma, but the role of CD8+ T memory cells (Tms) in asthma remains unknown. Here, we analyzed the variation of CD4-Tms in asthmatic mice so ...
在健康小鼠的外周血液中,首先根据它们的物理参数(FSC和SSC),然后根据CD45、CD3、CD4和CD8标记的表达,识别出四个T淋巴细胞亚群,即TH CD4+(62.8%)、TC CD8+(34.53%)、DN(2.56%)和双阳性(DP)(0.12%)。基于表达CD44和CD62L区分效应细胞和记忆细胞。初始T细胞表现...
This study investigated the role of T cell function in age-related unresponsiveness to PD-1 blockade cancer therapy. We found inefficient generation of CD44 low CD62L low CD8 T cell subset (P4) in draining lymph nodes of tumor-bearing aged mice. In vitro stimulation of naive CD8 T cells ...