Human double- negative (CD4-CD8-) T cells bearing alpha beta T cell receptor possess both helper and cytotoxic activities. Clin Exp Immunol. 1991;85(3):525-30.Matsumoto M, Yasukawa M, Inatsuki A, Kobayashi Y (1991) Human double-negative (CD4−CD8−) T cells bearing alpha beta T ...
A minor population of αβ T cells expresses neither CD4 nor CD8. These cells are probably heterogeneous. They are widespread in anatomical distribution, express an abnormal T-cell repertoire largely unaffected by selective processes that act on CD4 + and CD8 + T cells, and exhibit both cytotoxi...
Double negative T (DNT) cells are a unique subset of T lymphocytes that do not express CD4, CD8, or natural killer cell markers, and studies have suggested that DNT cells play critical and diverse roles in the immune system. However, the role of intrahepatic DNT cells in NAFLD is largely...
双阴性T细胞分离试剂盒,用于通过顺次分选从PBMC中分离双阴性T细胞(CD4–CD8–CD56–CD3+TCRα/β+细胞)。 分离过程分为两步。为了除去所有不需要的TCRα/β+细胞,首先对CD4+,CD8+和CD56+细胞进行间接磁标记和去除。 同时使用Anti-TCRα/β-PE进行标记。 在第二步中,将带有预富集的双阴性T细胞与Anti-PE Micro...
2023年6月《Nature Immunology》杂志发表了一篇题为“Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors”的文章,研究团队通过MHC-II类缺陷型鳞状细胞癌肿瘤模型(SCC VI...
D. Impact of persistent HIV replication on CD4 negative Vgamma2Vdelta2 T cells. The Journal of infectious diseases 205, 1448-1455, doi: 10.1093/infdis/jis217 (2012).Boudová S, Li H, Sajadi MM, Redfield RR, Pauza CD (2012) Impact of persistent HIV replication on CD4 negative Vγ2V...
K. & Blankenstein, T. Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression. J. Clin. Invest. 129, 324–335 (2019). Article PubMed Google Scholar Corthay, A. et al. Primary antitumor immune response mediated by CD4+ T cells...
To address the molecular mechanism, we found that after TCR stimulation, CD4(+) T cells from PKO mice display an increased intracellular calcium flux and subsequently enhance activation of transcription factor NFAT1. Our results indicate that perforin plays a negative role in regulating CD4(+) T ...
Interestingly, the normal immune profile ofadult HIV-negativeindividuals living in Africaalso exhibit chronic immune activation, reminiscent of that observed in HIV-1 infected individuals. 论文讨论了Chronic immune activation(长期/慢性免疫系统免疫能力异常)的细胞级别机制:naïve CD4+ T细胞数量减少,memory CD...
T cells are the central mediators of both humoral and cellular adaptive immune responses. Highly specific receptor-mediated clonal selection and expansion of T cells assure antigen-specific immunity. In addition, encounters with cognate antigens generate