b)在邻近的淋巴组织中,它们还改变具有经典Th和Tfh细胞功能的DC和B细胞的抗原提呈(CD40L、IL-21)。 c)在TME中,CD4+T细胞通过细胞因子产生和细胞毒性抑制肿瘤生长,既直接影响肿瘤细胞,又影响血管。 d)与CD4+T细胞抗肿瘤反应的许多方面相反,它们还通过CD4+ Treg和Tfh细胞功能促进肿瘤生长,例如IL-2消耗和通过CTLA-...
b)在邻近的淋巴组织中,它们还改变具有经典Th和Tfh细胞功能的DC和B细胞的抗原提呈(CD40L、IL-21)。 c)在TME中,CD4+T细胞通过细胞因子产生和细胞毒性抑制肿瘤生长,既直接影响肿瘤细胞,又影响血管。 d)与CD4+T细胞抗肿瘤反应的许多方面相反,它们还通过CD4+Treg和Tfh细胞功能促进肿瘤生长,例如IL-2消耗和通过CTLA-4...
A lung cancer study using single-cell sequencing has discovered certain exhausted CD4+T cell subsets in TME. Certain evidence suggested that the enrichment of exhausted CD4+T cells is associated with increased CD1C+DC population [47], and in some subsets, the expression ofLag3andTim3increased w...
Medians are shown and were analyzed by two sided unpaired Mann-Whitney U test (n = 9 for Untx and n = 5 for 9H10 aCTLA4 group). Source data Extended Data Fig. 7 CD4 T cell help is required for effector CD8 differentiation in TDLNs. a-c) Th1 differentiation and tumor ...
Transcriptional analysis of Th-ctx melanoma-reactive CD4+ T cells revealed high Prdm1 and Tbx21 expression and decreased expression of Tfh signature genes. IL-2 was central to the acquisition of the cytotoxic program in CD4+ T cells, functioning in a Blimp-1-dependent manner, and independent ...