CD4 and CD8 T Cells with Different Functional Activities 1Takahashi, TsuyoshiDejbakhshjones, SussanAlerts, Email
CD4+辅助性T细胞和CD8+细胞毒性T细胞是在胸腺中由同时表达CD4和CD8的共同祖细胞产生的。 这些双阳性(DP)胸腺细胞发育成CD4单阳性(SP)细胞和CD8 SP细胞,其过程受到两个关键TFs的相互表达的严格调控,即ThPOK(T-helperinducing POZ/Krüppel-like factor)和RUNX3(Runt-relate...
CD4+辅助性T细胞和CD8+细胞毒性T细胞是在胸腺中由同时表达CD4和CD8的共同祖细胞产生的。 这些双阳性(DP)胸腺细胞发育成CD4单阳性(SP)细胞和CD8 SP细胞,其过程受到两个关键TFs的相互表达的严格调控,即ThPOK(T-helperinducing POZ/Krüppel-like factor)和RUNX3(Runt-related transcription factor 3)。ThPOK是CD4+辅助...
At the CD4+CD8+ stage, thymocytes that express mature TCR-Alpha/TCR-Beta develop into one of many lineages. These lineages include conventional naive CD4+ and CD8+ T-cells, NKT (Natural Killer T-cells), Treg cells (CD4+CD25+ Regulatory ...
2024年6月20日,来自纪念斯隆·凯特琳癌症中心的Andrea Schietinger团队在Cancer Cell杂志上发表了文章Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors,他们证明肿瘤反应性CD4+和CD8+ T细胞...
ThPOK和RUNX3是控制CD4和CD8细胞命运和CTL效应程序的关键转录因子。 CD4+辅助性T细胞和CD8+细胞毒性T细胞是在胸腺中由同时表达CD4和CD8的共同祖细胞产生的。 这些双阳性(DP)胸腺细胞发育成CD4单阳性(SP)细胞和CD8 SP细胞,其过程受到两个关键TFs的相互表达的严格调控,即ThPOK(T-helperinducing POZ/Krüppel-like fact...
Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon Article Open access 18 October 2021 References Bazan, J.F. Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA 87, 6934–6938 (1990...
The selection model postulates that precursor DP T cells randomly choose a fate and lose expression of either CD4 or CD8. Further differentiation and survival depends on the cell having chosen correctly, so that it receives a signal from coordinate binding of the TCR and co-receptor to a self...
Programmed cell death-1 (PD-1) is an immune checkpoint molecule expressed at high levels on the surface of exhausted HIV-specific CD4+ and CD8+ T cells8,9,10,11,12. Its blockade enhances CD4+ T cells and CD8+ T cells functions during Simian immunodeficiency virus infection13,14. In addi...
近日,来自德国马格德堡大学的Thomas Tüting团队在Nature上在线发表题为 CD4+T cell-induced inflammatory cell death controls immune-evasive tumours 的文章,揭示了仅少量CD4+T细胞就足以消除逃逸直接CD8+T细胞靶向的MHC缺陷肿瘤的分子机制,证明CD4+T细胞和肿瘤杀伤性髓细胞共同协调诱导远程炎性细胞死亡以间接消除INF无反...