相反,Th2细胞及其产生的IL-4通过将肿瘤相关的巨噬细胞(TAMs)极化为免疫抑制表型而与促肿瘤功能和免疫抑制有关。 Th17细胞及其衍生的细胞因子参与TME的炎症反应,从而促进肿瘤生长和免疫抑制。 Tregs、iTregs和它们产生的细胞因子,如IL-10和TGF-β,以及细胞与细胞的直接相互作用(如CTLA4)抑制DC的激活,改变CD4+T细胞的...
[7]Froidure A, Shen C, Gras D, et al. Myeloid dendritic cells are primed in allergic asthma for thymic stromal lymphopoietin-mediated induction of Th2 and Th9 responses. Allergy, 2014, 69(8): 1068-1076 [8]Zhu J, Paul W E. CD4 T cells: fates, functions, and faults. Blood, 2008,...
因其功能的不同,可将CD4+T细胞分为Th1、Th2、Th3、Treg、Tr1、Tfh、Th17、Th9和Th22等Th细胞亚群。各大Th细胞亚群之间相互协调,共同发挥免疫调节作用,维持机体稳态。 Th细胞一家子 ▉Th1概述 生物学功能:Th1主要分泌IL-2、IFN-γ、TNF-β等Th1型细胞因子,这些细胞因子可...
Th22参与了在银屑病,强直性脊柱炎、桥本甲状腺炎,和多发性硬化症。 另一个亚群Tfh(卵泡辅助性T细胞)促进B细胞的抗原特异性发育并分泌IL-21。滤泡辅助性T细胞(T follicular helper cells, Tfh),是体液免疫中辅助B细胞产生抗体的T细胞亚群。在淋巴组织的T细胞...
cells相关的lncRNAs在肝细胞癌中的预后价值,并探索了与免疫微环境之间的关系。对于该思路有兴趣的老师可以与我们联系,方法适用于其他疾病。 背景: 肝细胞癌(hepatocellular carcinoma,HCC)是癌症相关死亡的第二大原因,在世界范围内的发病率不断上升。HCC主要通过手术(切除和移植)和/或多种辅助治疗联合治疗,但是HCC的患...
Cluster T6 was characterized as naive CD8+ T cells with the high expression of CCR7, LEF1, and CD27. 更多的时候其实是打分,并不能完全是看某个基因或者某些基因在某个单细胞亚群里面的排他性的特异性高表达,比如 resident, cytotoxic, exhausted, and costimulatory score for CD8 T cells. ...
Loo TT, Gao Y, Lazarevic V. Tranional regulation of CD4+ TH cells that mediate tissue inflammation. J Leukoc Biol. 2018 Dec;104(6):1069-1085. Yi J et al. Antigen-specific depletion of CD4+T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoim...
由CD4+Teff细胞分泌的细胞因子可以招募和支持先天效应细胞(innate effector cells),如Th1招募的巨噬细胞(macrophages )和Th2招募的嗜酸性粒细胞和嗜碱性粒细胞。相反,Tfh可与T-B交界处的B细胞相互作用,进入次级淋巴器官的GC,通过 Tfh1 cells分泌的IFN-γ 和Tfh2 cells分泌的IL-4 ,促进类别转换( class-switching...
cells. Th Full size image Table 1 Examples of tumour-associated antigens with MHC II-restricted epitopes cited in this review. Full size table In contrast, although the development and effector functions of distinct subsets of CD4+T cells has been recognised and described (Fig.1), the interpla...
multifunctional CD4 T cellsCD4 T-cell subsetsTfh cellsTh1th2Th22CD4(+) T-cells have been shown to play a central role in immune control of infection with Plasmodium parasites. At the erythrocytic stage of infection, IFN-纬 production by CD4(+) T-cells and CD4(+) T-cell help ...