RORγt调节Th17特征细胞因子IL-17A,IL-17F,IL-22以及IL-23受体,CCL20和CCR6的表达[4]。除Th17细胞外,还报道了其他细胞类型中RORγt及其靶细胞因子的表达,如CD8+Tc17细胞,不变的自然杀伤T细胞,ILC3和γδT细胞[5]。越来越多的...
Th2细胞由TF GATA-3表达和细胞因子IL- 4、IL-5和IL-13的分泌而分化,可以保护宿主免受蠕虫感染,促进组织修复,并促进慢性炎症,如哮喘和过敏。由树突状细胞(DCs)和先天淋巴样细胞ILC2分泌的IL-4与CD4+T细胞上的IL-4R结合,通过STAT6磷酸化促进GATA-3的表达,并随后产生Th2相关的IL4,IL5,IL13细胞因子。激活的...
Th2细胞由TF GATA-3表达和细胞因子IL- 4、IL-5和IL-13的分泌而分化,可以保护宿主免受蠕虫感染,促进组织修复,并促进慢性炎症,如哮喘和过敏。由树突状细胞(DCs)和先天淋巴样细胞ILC2分泌的IL-4与CD4+T细胞上的IL-4R结合,通过STAT6磷酸化促进GATA-3的表达,并随后产生Th2相关的IL4,IL5,IL13细胞因子。激活的...
IL-4 and IL-13 are two cytokines mainly secreted by Th2 cells, in addition, Tfh and group 2 innate lymphoid cells (ILC2s) have also been found to be important sources of IL-4 and IL-13, respectively [209]. IL-4 and IL-13 genes are located in the same vicinity on chromosome 5, ...
The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of Rora across CD4+ T cells in general, but with an emphasis on Th2 cells, both in vitro as well as in the co...
Poor access to Notch1 ligands due to the migratory defect present in Gnai2fl/flvav1-cre DN1 thymocytes could account for this iFOosbuPssre9etvh-rDeverarLeti1ilmoycnpiem.llHliscpoadatwoiirneeesgvdenGrio,nαtdtrii2hereisenccGtuNleynomaptilc2aahrtflig/snfliivnggaanGvla1αzl-oiicn2nrgdee,...
自然杀伤(NK)细胞作为机体固有免疫体系里的关键效应细胞,在抵御病毒侵袭以及清除肿瘤细胞等方面承担着极为重要的使命。NK 细胞群体具有显著的异质性,是由多个在表型特征与功能表现上均存在差异的细胞亚群所构成。不过,以往针对 NK 细胞在疾病进程中所起作用的相关研究,往往只是把 NK 细胞当作一个统一的整体来对待,至于...
MHCII,andgeneticdeletionofILC3-intrinsic MHCIIresultedinspontaneousCD4 + Tcell– dependentintestinalinflammation(22),sug- gestingthatadditionalantigen-presentation pathwayscontrolcommensalbacteria–specific CD4 + Tcellpopulations. CCR6-expressinglymphoidtissueinducer(LTi)– likeILC3s(CCR6 + ILC3s)areamajor...
ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut Article 07 September 2022 Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity Article 06 November 2023 Introduction...
要］ CD4+T 细胞作为细胞免疫的主要武器，在控制和清除感染方面起着至关重要的作用，是机体抵抗感染性疾病 的重要屏障。流感病毒感染引起的呼吸道感染性疾病具有极高的传染性、发病率及病死率，其感染机制较为复杂，尚未得到全面阐述。机体在流感病毒感染后诱发的旺盛免疫反应被称为“细胞因子风暴”，与过激的促炎...