CD33+ populations within the TME are enriched for HLA-DR– populations and comprise different MDSC sub- sets, including C D33+HLA-DR–CD14+CD15– monocytic MDSCs, CD33+CD14+CD15– polymorphonuclear MDSCs and CD33+HLA-DR–CD14–CD15– immature or early-stage MDSCs [32]. Since...
Immature myeloid cells (HLA-DR−/lowCD33+CD16−) were tested before and after granulocyte colony-stimulating factor (G-CSF) administration in healthy donor and isolated for suppression assays and co-culture with T cells in vitro. Isolated cells were infused in humanized mice for a xenogeneic ...