CD301b is also known as macrophage galactose-type C-type lectin 2 (MGL2). CD301b expression is restricted to dermal dendritic cells, connection tissue, and bone marrow derived dendritic cells. Macrophages also express CD301b at low levels. CD301b contains a single carbohydrate recognition...
MGL2/CD301b 蛋白, Mouse (HEK293, His) 英文名称: 国产/进口: 进口 产地/品牌: MedChemExpress(MCE) 型号: 10 μg 参考报价: 1100 销售商: 上海皓元生物医药科技有限公司 总点击数: 124 更新日期: 2025-02-13 产品类别: 生化试剂 性能参数 MCE 的所有产品仅用作科学研究或药证申报,...
CD301b+DCs 调节 Tfh 细胞命运:研究人员还发现,CD301b+DCs 不仅促进 Th2 细胞分化,还通过其内在的 CD40–IL-2 轴限制 CD4+T 细胞向 Tfh 细胞的分化,推动其向非 Tfh 效应 Th 细胞命运发展,进一步完善了对 CD301b+DCs 在免疫调控中作用的认识。 综上所述,该研究揭示了 CD301b+DCs 内在的 CD40–IL-2...
Nave mouse skin is populated with three major DC subsets, including epidermal Langerhans cells, CD103+ dermal DCs and CD301b+ dermal DCs, all of which migrate to the draining lymph nodes (dLNs). We showed previously that CD301b+DCs are required for the differentiation of antigen specific T...
Mouse Macrophage Galactose N-acetyl-Galactosamine (GalNAc) specific Lectin 2 (MGL2), also known as CD301b, is a 38 kDa member of the C-type lectin family (1). Two MGL proteins are encoded by separate genes in the mouse, but share 91% amino acid (aa) identity in the extracellular dom...
CD301b+macrophages are essential for effective skin wound healing. Shook B,Xiao E,Kumamoto Y,et al. Journal of Investigative Dermatology . 2016Shook B, Xiao E, Kumamoto Y, Iwasaki A, Horsley V: CD301b+ macrophages are essential for effective skin wound healing. J Invest Dermatol 2016, 136...
CD301b+DCs are required for Th2 cell differentiation induced by papain (protease allergen), alum (type 2 adjuvant), andNippostrongylus brasiliensis(Nb) (helminth parasite)13, but whether they instruct the Th2 cell fate through a cognate interaction or via antigen-independent cues (e.g., cyt...
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Here, we have examined the requirement for CD301b+ DDCs in the generation of Th2 cell-mediated immunity following immunization with antigen plus papain. We have extended our analysis to another widely used Th2-type adjuvant, alum, as well as to a natural rodent pathogen, Nippostrongylus ...
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