In human tonsils, expression of the CD27 antigen is found on memory B cells, germinal center B cells, subepithelial marginal zone B cells, and plasma cells. CD27 is further expressed on specific T cell subsets and NK cell subsets. Applications T cells can be pre-selected using the CD8+ ...
It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD7 on lymphocytes and dendritic cells. The CD27-CD7 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and ...
抗体名:Varlilumab靶点:CD27L receptor, TNFRSF7, T14, CD27 antigen, Tumor necrosis factor receptor superfamily member 7, CD27, T-cell activation antigen CD27 宿主:Homo sapiens适应物种:Human 克隆性:Monoclonal药物对照抗体:Varlilumab Tags:Varlilumab 代理商,Varlilumab 价格,Varlilumab 供应商, Varl...
25, 26, 27 GC-derived *plasmablast-like” B cells are increased in human cGVHD.11 Recent studies have shown that the latter cell subset bears regulatory properties and may be the main IL-10–producing B-cell subset in mice.28, 29, 30, 31 Discrepancies in the cell surface antigens ...
Strategies for targeting CD70 have explored scFvs or engineering its natural receptor (CD27) as the antigen-recognition moiety of a CAR. Recent studies demonstrate improved preclinical antitumor activity using the CD27 ligand compared to scFv-based CAR, suggesting functional advantages associated with ...
IL-1RT1, IL-1R-alpha, mIL-1R1, CD121a, IL-1R-1, sIL-1RI, IL1RT1, IL1R1, sIL-1R1, IL1R, CD121 antigen-like family member A, Interleukin-1 receptor type I, Interleukin-1 receptor alpha, mIL-1RI, IL1RA, IL-1RT-1, Interleukin-1 receptor type 1, p80 ...
AML, acute myeloid leukaemia; CAR-T cell, chimeric antigen receptor gene-modified T cell; CD27, cluster of differentiation 27; CD70, cluster of differentiation 70; DC, dentritic cell; FDA, Food and Drug Administration; mAb, monoclonal antibody; 6MHP, 6 melanoma helper vaccine comprised of 6...
Moreover, the OnCD27 transcripts presented a higher expression level in IgMlo plasma-like cells than IgMhi activated B cells. In summary, the collective results may provide that OnCD27 plays roles in T cell-dependent response and B cell differentiation in Nile tilapia. 展开 关键词: ...
This subset, whose responses are readily elicited by phosphoantigens, plays an important role in anti-tumor immune responses. This study shows that most Vγ9Vδ2+ cells express CD27, and signaling via the CD27-CD70 axis is needed for their survival, proliferation and cytokine secretion. More...
Innate-like B cell subsets during immune responses: beyond anti- body production. J Leukoc Biol. 2019;105:843–56. 27. Chang LY, Li Y, Kaplan DE. Hepatitis C viraemia reversibly maintains subset of antigen-specific T-bet+ tissue-like memory B cells. J Viral Hepat. 2017;24:389–96. ...