INDUCED CD4+CD25+FOXP3+ REGULATORY T CELLS AND IMPAIRED DEVELOPMENT OF CD8+CD44+CD62L+ MEMORY T CELLS PROMOTE SPECIFIC TOLERANCE TO CARDIAC ALLOGRAFTS FOLLOWING RAPAMYCIN TREATMENT: 1859.An abstract is unavailable. This article is available as a PDF only....
CD45RAnegCD45RO + CIM5RBlow) ,其表面还表达 CD5 ,CD11a/CD18 ,CD44 ,CD62L 和 CD54 分子 ,而 CD45RB ,CD69 的表达水平较低 ,大约 60%的 CD4 CD25 调控 T 细胞表达 CD38 。另外 ,这些细胞表面 还高水平表达被推测为调节标志的 CTLA-4 和 GITR ...
【摘要】 CD4+CD25+调节性T细胞是一群表型和功能特异的T细胞亚群，具更免疫无能和免疫抑制两大特性，通过细胞直接接触或分泌抑制性细胞因子发挥对CD4+CD25-T细胞的抑制作用。GVHD是异基因造血干细胞移植最严重的并发 症之一，近来更关CD4+CD25+调节性T细胞与GVHD关联性的研究得出了两种截然相反的结论，即该类细胞可...
nbsp;nbsp;nbsp; 此外,小鼠和人体内CD4+CD25+调节性T 细胞的表面分子表达CD45RBlow,CD5high,CD44high,ICAM-1high,LFA-1high(在小鼠为CD45RBlow,人为CD45RAnegCD45RO+ CD45RBlow),其表面还表达CD5,CD11a/CD18,CD44,CD62L和CD54分子,而CD45RB,CD69的表达水平较低,大约60%的CD4+CD25+调控T细胞表达CD38...
CD45RBI叭 CD5h CD44h A- 4 、I c A gh、 IL- 2Rp 链∞ 122)、转铁蛋白受体(cc)-f1)和 MHD II 类分子 等。几乎所有的 cc c [)25.T 细胞都 表达低水平 的 CD45RB。 表明 处于活化状态。 c 【 C 5叮 细胞可分为 CD4 C: D'25hifghT 细胞和 CD4+CD251oNT 细胞 .具有 免疫抑 制活性...
品);抗rhIL-2、CD4一FITC、CD-25-PE、FOXP3一PE—cy5、CD4一FITC、CD44一PE、CD62L—PE、CD8-FITC单 克隆抗体及同型对照、破膜剂、固定剂(美国 eBioseience公司产品),RPMI一1640培养液、优质 胎牛血清和青霉素、链霉素双抗(美国Gibco公司产 品),红细胞裂解液(美国Sigma公司产品)。C1M+CD25+Treg、CD4+CD2...
Here we show that the majority of the enteroantigen-specific CD4 1 CD25 ÿ T cells are naive cells expressing a CD45RB high, CD62L high and CD44 low phenotype. These cells are also present in the thymus and data from adult thymectomized mice show that they represent late (>6 weeks)...
CD69−Treg4, in the regulation of humoral immunity. These observations highlight the protective role of CD25+Treg in systemic autoimmunity; however, the disease induced by the absence of functional CD25+Treg is quite different from SLE1,5. Moreover, a role for CD25+Treg in SLE has not ...
OT-I T cell maturation markers were assessed by flow cytometry using rat anti-mouse CD8a-PerCP (no. 553036), rat anti-mouse CD44-FITC (no. 553133), rat anti-mouse CD62L-APC (no. 553152) and rat anti-mouse CD11a-PE (no. 553121) and appropriate isotype controls (all by BD ...
Here, we found that most of the CD4+CD25+ T cells in the small intestinal lamina propria (LP) express Foxp3 and exhibit an ‘effector/memory’ phenotype, CD44hiCD45RBloCD62L−, whereas only a minority of the Foxp3+CD4+CD25+ T cells in the spleen and mesenteric lymph nodes showed ...