有两大类肿瘤相关巨噬细胞(tumor-associated macrophage, TAM):M1和M2。M1巨噬细胞吞噬细菌、病毒和癌细胞,并引起炎症。M2巨噬细胞促进组织从炎症中恢复过来。当M2巨噬细胞无法正常工作时,慢性炎症会导致诸如纤维化之类的疾病。纤维化是因胶原蛋白过度表达而导致的结缔组织沉积。 这些研究人员发现RP-182将M2巨噬细胞...
巨噬细胞可以存在两种不同的表型,即促炎(M1)和抗炎(M2)表型。因此,将巨噬细胞从M1表型转换为M2表型是治疗炎症的一种潜在方法。通常通过对M1(iNOS,红色)和M2(CD206,绿色)标记物进行免疫荧光染色来评估巨噬细胞的表型变化。图1可以看出在FA-AgNPs处理后,iNOS(M1标志物...
and stimulate angiogenesis and invasion of tissues.M2 macrophages are predominant.CD206 is a M2 macrophage marker with high specificity and plays an important role in tumor cell proliferation and metastasis.Studies have shown that CD206 is closely related to malignant tumors such as breast cancer,...
Raggi F, Pelassa S, Pierobon D et al. Regulation of Human Macrophage M1–M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1. Front Immunol. 2017; 8: 1097.小鼠的巨噬细胞检测，也可以参考此方法，加上F4/80和CD11b作为上级门，圈出总的巨噬细胞。
A soluble form of CD206 is generated by cleavage of the full-length protein, and it can be detected in in vitro macrophage cell culture supernatants and in mouse serum. CD206 is considered to be one of the markers of M2 macrophages. Factors inducing its expression include: IL-4, IL-13,...
有两大类肿瘤相关巨噬细胞(tumor-associated macrophage, TAM):M1和M2。M1巨噬细胞吞噬细菌、病毒和癌细胞,并引起炎症。M2巨噬细胞促进组织从炎症中恢复过来。当M2巨噬细胞无法正常工作时,慢性炎症会导致诸如纤维化之类的疾病。纤维化是因胶原蛋白过度表达而导致的结缔组织沉积。
参考文献: 1.Chavakis, T., Alexaki, V.I. & Ferrante, A.W. Macrophage function in adipose tissue homeostasis and metabolic inflammation. Nat Immunol (2023). https://doi.org/10.1038/s41590-023-01479-0
A soluble form of CD206 is generated by cleavage of the full-length protein, and it can be detected in in vitro macrophage cell culture supernatants and in mouse serum. CD206 is considered to be one of the markers of M2 macrophages. Factors inducing its expression include: IL-4, IL-1...
the well-characterized M2-like macrophage markers CD163, and MgL2. We determined that the F4/80 + CD206 − population expressed higher level of CD11c, TNFα, IL-6, Zbtb46 mRNA (Fig. 1b, red) than the F4/80 + CD206 + population, indicating that the former includes substantial amount...
M2 macrophage marker CD206 and tumor 引用 收藏 分享 摘要 肿瘤相关巨噬细胞存在于肿瘤进展的所有阶段,起到促进血管生成、组织侵袭等作用,其中以M2型巨噬细胞居多。CD206是M2型巨噬细胞标志物,具有高度特异性,与肿瘤细胞的增殖和转移密不可分。已有研究表明CD206与乳腺癌、卵巢...展开更多 Tumor-associated ...