NK gene complex and the Leukocyte Receptor Complex in humans; (3) CD160 expression is associated to the CD56dim CD16+ cytotoxic NK cell phenotype; (4) both human and mouse CD160 recognize MHC class Ia and Ib molecules; (5) unlike the other MHC class I-dependent activating NK receptors,...
4. CD160-activating NK cell effector functions depend on the phosphatidylinositol 3-kinase recruitment.[J].Aguerre-Girr M;Polgar B;El-Costa H;Marie-Cardine A;Bensussan A;Valitutti S;Rabot M;Barakonyi A;Le-Bouteiller P,International Immunology.2007,第4期 5. Cloning of BY55, a novel Ig s...
CD160 (also Natural killer cell receptor BY55) is a 27-30 kDa member of the Ig superfamily. In human, it is expressed principally on nonmyeloid hematopoietic cells. These include CD56DIMCD16+ cytolytic NK cells, CD8+CD28- T cells, CD8+CD101+ IELs, NKT cells, gamma δ TCR T cells,...
中文名称:NK细胞受体BY55抗体;CD160 英文名称:CD160 别名:By55; Natural killer cell receptor BY55; BY55; CD160 antigen [Precursor]; CD160 molecule; FLJ46513; Natural killer cell receptor BY55; NK1; NK28; BY55_HUMAN. 产品介绍: CD160是一种27kda的糖蛋白,最初用单*抗体经55鉴定。其表达与外...
The binding of CD160 to both classical and non-classical MHC I enhances NK and CD8+ cytotoxic T lymphocyte functions (PMID: 25179432). CD160 is a ligand for HVEM (herpes virus entry mediator) and the binding of CD160 to HVEM inhibits T cell activity (PMID: 19426226). 实验方案 Product ...
CD160 (also BY55) is a 27 kDa member of the immunoglobulin superfamily of molecules. It is expressed on select hematopoietic cell types, including CD56dimCD16+cytotoxic NK cells, CD8+CD28-effector T cells, δ/ gamma T cells, and restricted CD4+T cells. It is a receptor for HLA-C molec...
BY55; BY55_HUMAN; CD160; CD160 antigen [Precursor]; CD160 antigen; CD160 delta Ig; CD160 molecule; CD160 transmembrane isoform; FLJ46513; Natural killer cell receptor BY55; Natural killer cell receptor; immunoglobulin superfamily member; NK1; NK28 ...
CD160 蛋白 与 MHC I 弱结合,并刺激 NK 和 CD8+ T 细胞活化。 研究背景:CD160 是一种 27 kDa 糖蛋白,是免疫球蛋白蛋白质“超家族”的成员。CD160最初是用单克隆抗体BY55鉴定的。据报道,CD160 由 NK 细胞、NKT 细胞、上皮内 T 细胞、γδ TCR+ T 细胞以及记忆表型、激活和效应 CD8+ T 细胞表达。
It is expressed on select hematopoietic cell types, including CD56dim CD16+ cytotoxic NK cells, CD8+ CD28- effector T cells, delta/ gamma T cells, and restricted CD4+ T cells. It is a receptor for HLA-C molecules, and its engagement induces CD160+ NK cells to both secrete IFN-g...
The invention also relates to antibodies or fragments thereof, chimeric antigen receptors (CARs) and bi-specific T cell engagers (BiTEs) which comprise such CD160 binding domains. Modalities targeting CD160 may be useful in the treatment of cancerous diseases such as NK lymphoma, TCRγδ ...