2011. HIV inhibits early signal transduction events triggered by CD16 cross-linking on NK cells, which are important for antibody-dependent cellular cytotoxicity. J Leukoc Biol 89:149 -158. http: //dx.doi.org/10.1189/jlb.0610371.Lichtfuss GF, Meehan AC, Cheng WJ, Cameron PU, Lewin SR, ...
On NK cells, signal transduction by CD16 is mediated through the γ chain, and cross-linking of CD16 with immune complexes or CD16-specific mAbs induces calcium mobilization and hydrolysis of membrane phosphoinositides.Access through your organization Check access to the full text by signing in ...
Crosslinking of CD16 in natural killer cells and monocytes results in activation of the MAPK and PI3K signaling pathways, thus regulating the production of TNF alpha, IL-6, and IL-1 beta. This monoclonal antibody has been shown to block Fc receptor functions. 产品留言 标题 联系人 联系...
Description: This B73.1 monoclonal antibody reacts with human CD16, a member of the Fc receptor family also known as Fc gamma RIIIa and Fc gamma RIIIb. This 50-65 kDa receptor is expressed on natural killer cells, neutrophils, monocytes, and macrophages. Crosslinking of CD16 in natural ...
Crosslinking of CD16 in natural killer cells and monocytes results in activation of the MAPK and PI3K signaling pathways, thus regulating the production of TNF alpha, IL-6, and IL-1 beta. This monoclonal antibody has been shown to block Fc receptor functions. 产品留言 标题 联系人 联系...
The binding of antibody-antigen complexes to activatory and inhibitory FcγRs induces their cross-linking and subsequent signaling through immunoreceptor tyrosine-based activation motifs (ITAMs) and inhibition motifs (ITIMs), respectively. Cytoplasmic signaling includes an increase in intracellular calcium ...
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*Kocher M, Siegel ME, Edberg JC, Kimberly RP: Cross-linking of Fc gamma receptor IIa and Fc gamma receptor IIIb induces different proadhesive phenotypes on human neutrophils. J Immunol. 1997 Oct 15;159(8):3940-8. [Abstract] *Arase N, Arase H, Hirano S, Yokosuka T, Sakurai D, Saito...
We also measured cytokine (IL-2) secretion of Jurkat T-CD16A cells bound to BiKEs after cross-linking, which was achieved by either bivalent mouse anti-FLAG antibody or by 293T-gp160SC cells. Co-incubation of Jurkat T-CD16A cells with BiKEs opsonized 293T-gp160SC cells resulted in relea...
This study demonstrates that GTP-binding proteins regulate Fc gamma RIII-mediated signal transduction and inositol phosphate (IPn) generation in human NK cells. In addition the cross-linking of CD16 by mAb, guanosine 5'-o-3-thiophosphate induced 1,4,5 inositol trisphosphate (IP3) release in pe...