该研究首次在人源化CD147转基因小鼠(hCD147TG)肝细胞癌模型中,系统性比较了CD147 CAR-NK与CD147 CAR-T疗法的OTOT及神经毒性差异,为CAR-NK疗法的临床转化提供了关键安全性数据。 结果显示,CD147 CAR-NK在体内外均表现出显著的安全...
CAR-T细胞(ChimericantigenreceptorTcell,简称CAR-Tcell)是一种表达嵌合抗原受体的T细胞。嵌合抗原受体T细胞技术为临床治疗癌症提供了新的方向。该方法通过提取患者体内的T细胞,经体外改造培养,将携带有特异序列的载体整合进入到正常T细胞中,使其形成CAR-T。改造后的CAR-T细胞具有特异性识别和攻击杀伤肿瘤细胞的能力,回...
军医大学国家分子医学转化科学中心经过多年研究,充分揭示了 CD147 靶点在主要疾病发生发展中的重要作用机制,并进行了系统的专利保护,率先实现 CD147 靶点药物的临床转化并取得重大突破。“抗 CD147 人源化单抗药物、基因修饰 T 细胞治疗制剂(T 细胞受体 TCR 和嵌合抗原受体 CAR)”被列入《重点领域技术路线图》。公...
(7) The hCD147KI-NSG background with hACE2 mouse model can be used to test novel immunotherapies (e.g., CAR-NK) to prevent and/or treat new mutants of SARS-CoV-2 in the future. In summary, the newly generated hCD147KI-NSG mouse model can be used as a platform where direct ...
Zheng HC, Wang W, Xu XY, Xia P, Yu M, Sugiyama T, et聽al. Up-regulated EMMPRIN/CD147 protein expression might play a role in colorectal car- cinogenesis and its subsequent progression without an alteration of its glycosylation and mRNA level. J Cancer Res Clin Oncol. 2011;137(4):585...
19:145 https://doi.org/10.1186/s12931-018-0851-7 RESEARCH Open Access Influenza A virus infection dysregulates the expression of microRNA-22 and its targets; CD147 and HDAC4, in epithelium of asthmatics Fatemeh Moheimani1,2* , Jorinke Koops1,2,3, Teresa Williams1,2,4, Andrew T. Re...
1 h, r.t. 3. Results Since SARS-CoV-2 is able to infect different organs, we tested four different human cell lines (A549 and CaLu3 from lungs, HepG2 from liver, and CaCo2 from intestine) as model systems to study viral infection and used Vero E6 cells from African green monkey ...
Since most of the key immune cells, such as NK, T, and B cells, are not productively infected by HCMV, previous studies mainly focused on how the infection of permissive myeloid lineage or stromal cells alters the ability of these cells to prime and activate NK (natural killer cell) and...
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He didn’t give any responses to my enquiry. 10 . flexible /ˈfleksəbl/ adj. 【paraphrase】 adj.that can be changed easily adj.灵活的,可变通的 ;有弹性的,可弯曲的 【formation】 同根词flexibility n.[U] 柔韧性;灵活性 / (反义) ...