New evidence suggests that levels of intermediate monocytes or CD16+(intermediate and non-classical) monocytes are increased in autoimmune diseases. However, studies regarding the role of each monocyte subset in the pathogenesis of Graves' disease (GD) are lacking. We aimed to investigate the ...
In human peripheral blood the classical CD14(++)DR(+) monocytes and the pro-inflammatory CD14(+)CD16(+)DR(++) monocytes can be distinguished. In erysipelas we found strongly increased numbers of CD14(+)CD16(+) monocytes on the day of diagnosis (day 1) in 11 patients with an average ...
单核细胞(monocytes)是一种单个核吞噬细胞,来源于骨髓髓样祖细胞,主要分布于人体血液循环系统,是人体免疫系统的重要组成部分,参与机体的免疫应答和炎症反应。单核细胞是重要的天然免疫效应细胞,在感染过程中能快速从外周血迁移到组织中,参与病原体的识别和清除。同时,单核细胞还是巨噬细胞(Macrophage)和树突状细胞(Den...
Peripheral blood was obtained from 143 patients suffering from PAOD (Rutherford stage I to VI) and three monocyte subsets were identified by flow cytometry: CD14++CD16− classical monocytes, CD14+CD16++ non-classical monocytes and CD14++CD16+ intermediate monocytes. Additionally the expression of ...
CD14(+)CD16(+) monocytes are the main target of Zika virus infection in periph- eral blood mononuclear cells in a paediatric study in Nicaragua. Nat. Microbiol. 2 (11), 1462-1470.Michlmayr, D.; Andrade, P.; Gonzalez, K.; Balmaseda, A.; Harris, E. CD14+CD16+ monocytes are the...
本文对单核细胞的亚型,CD14+CD16+细胞的主要特性,以及这一群CD14+CD16+单核细胞对于人类相关的一些疾病的影响进行简要综述。 [关键词]单核细胞;亚型;炎症;抗原提呈 [中图分类号]R392.12 [文献标识码]A ResearchprogressofCD14+CD16+subtypesmonocytes WANGXin,KANGFubiao,WANGGuiping,ZHANGGuomin Departmentof...
An increase in the classical monocyte fraction (CD14++/CD16) greater than 94.0% of total monocytes is considered highly sensitive and specific in distinguishing chronic myelomonocytic leukemia from other myeloproliferative disorders. In a pilot study of juvenile myelomonocytic leukemia cases, we noted ...
中间单核细胞(CD14+, CD16+) 非经典单核细胞 (CD14dim, CD16+) 经典的单核细胞表现出更多的促炎症表型,能够分泌可溶性细胞因子,并分化成树突状细胞,以桥接先天性和适应性免疫反应。中间单核细胞专门负责抗原呈递,在 HIV 感染中发挥重要作用。最后,非经典单核细胞负责抗病毒和抗肿瘤反应。
本文对单核细胞的亚型, CD14 + CD16 + 细胞的主要特性, 以及这一群CD14 + CD16 + 单核细胞对于人类相关的一些疾病的影响进行简要综述。[ 关键词 ] 单核细胞; 亚型; 炎症; 抗原提呈[ 中图分类号 ] R392.12 [ 文献标识码 ] AResearch progress of CD14 + CD16 + subtypes monocytesWANGXin, KANGFubiao...
In this regard, it has been observed that during TB infection, CD16 monocytes exhibit perturbation and are associated with disease severity. Monocyte subsets have also been shown to modulate their cytokine production under infectious and non-infectious conditions [14], [15]. A few other studies ...