Interestingly, CD11c high CD8 + T cells appeared only at a late stage of infection, expressed relatively high CD122 and low CD69, did not secrete IFN-纬, IL-10, TGF-尾, and exhibited much more potent cytotoxicity against target cells via Fas ligand鈥揊as pathway in an Ag-independent ...
in vivo targeting of dendritic cells, Immunohistochemistry (frozen) Castro FV, Tutt AL, White AL, Teeling JL, James S, French RR, Glennie MJ. (2008). "CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses" Eur J Immunol 38(8):2263-73....
This period also witnessed the recognition of several new classes of regulatory/suppressor cells including subpopulations of CD4 cells [5], NK cells [6], DCs [7], [8], CD8+ T cells [9], and B cells [10]. Each of these regulatory cells is known to possess distinct but sometimes ...
in vivo targeting of dendritic cells, Immunohistochemistry (frozen) Castro FV, Tutt AL, White AL, Teeling JL, James S, French RR, Glennie MJ. (2008). "CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses" Eur J Immunol 38(8):2263-73....
in vivo targeting of dendritic cells, Immunohistochemistry (frozen) Castro FV, Tutt AL, White AL, Teeling JL, James S, French RR, Glennie MJ. (2008). "CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses" Eur J Immunol 38(8):2263-73....
目的:改良CD11c细胞的磁珠分离方法,并观察CD11c细胞诱导同源CD4~+T和CD8~+T细胞增殖的作用。方法:使用胶原酶、DNase I和EDTA处理脾组织,以及小鼠血清和抗CD16/32抗体阻断CD11c磁珠与脾细胞非特异结合后分离CD11c细胞;流式细胞术分析CD11c细胞的纯度;淋巴细胞混合培养和ELISA检测CD11c细胞诱导同源T细胞增殖及分泌细胞因子...
(Wakim, Waithman, van Rooijen, Heath, & Carbone, 2008). However, the relative roles of steady-state CD11b+DCs and infiltrating inflammatory CD11b+DCs in activating memory CD8+T cell response have not been delineated (Wakim et al., 2008). CD11b+DCs in the skin and CD103+CD11b+...
日本血吸虫尾蚴感染小鼠CD8α - CD11c +型树突状细胞对哮喘的抑制作用
Taken collectively, current findings indicate thatCD11c+CD8+T cells, which are the main agents of anti-4-1BB mAb therapy, function sometimes as immune regulators by suppressing CD4+T cellnumbers/function, and sometimes as immune effectors. Interestingly, in both cases their activities are beneficial...
CD11c(+)CD8alpha(+) and CD103(+) dendritic cells (DC) have been shown to promote regulatory T cell responses and mediate tolerance in the gastrointestinal tract. These cells have also been identified in the lung, but their role in immunity to respiratory tract infection is not clear. In th...