cd11c+cd8α-dc细胞在免疫系统中扮演关键角色。对过敏性哮喘的发病机制研究不断深入。日本血吸虫可溶性虫卵抗原的提取有特定流程。免疫小鼠过程需严格控制实验条件与参数。不同剂量的抗原免疫小鼠效果存在差异。cd11c+cd8α-dc细胞的分离技术影响研究结果。过敏性哮喘症状表现多样且有个体差异。日本血吸虫可溶性虫卵抗原免疫...
Interestingly, CD11c high CD8 + T cells appeared only at a late stage of infection, expressed relatively high CD122 and low CD69, did not secrete IFN-纬, IL-10, TGF-尾, and exhibited much more potent cytotoxicity against target cells via Fas ligand鈥揊as pathway in an Ag-independent ...
日本血吸虫尾蚴感染小鼠CD8α - CD11c +型树突状细胞对哮喘的抑制作用
目的:研究日本血吸虫尾蚴感染鼠CD8ot—CD1lc型树突状细胞(Dc)在抑制过敏性哮喘中的作用。方法: 用磁珠分选方法纯化日本血吸虫尾蚴感染鼠及正常鼠DC亚群CD8c~一CD1lc细胞。将20只BALB/c小鼠随机均分为4 组,A组为过继转移日本血吸虫尾蚴感染鼠CD8ct—CD1lc型DC并诱发过敏性哮喘组。B组为过继转移正常鼠 ...
The N418 monoclonal antibody specifically reacts with the integrin alphax chain of the mouse CD11c, which is expressed on dendritic cells, CD4-/CD8+ intestinal intraepithelial lymphocytes (IEL) and some activated T lymphocytes. Low levels of CD11c were detected on mouse splenic natural killer cells...
CD11c(low)CD8(+) T cells, existing during the whole period of infection, act as conventional activated T cells to kill target cells in a perforin-dependent manner. Interestingly, CD11c(high)CD8(+) T cells appeared only at a late stage of infection, expressed relatively high CD122 and low ...
CD11c(+)CD8alpha(+) and CD103(+) dendritic cells (DC) have been shown to promote regulatory T cell responses and mediate tolerance in the gastrointestinal tract. These cells have also been identified in the lung, but their role in immunity to respiratory tract infection is not clear. In th...
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In vivo studies, however, showed a marked advantage of targeting Ag to CD11c for both CD4 (OT-II) and CD8 (OT-I) responses, with robust stimulation after a single, low dose (equivalent to 0.5 g OVA); in contrast, (anti-CD205 OVA) and (anti-MHC class II OVA) resulted in markedly...
CD11c 作为一正性调控 因子 ,参与 DCs 的黏 附、迁移 ,抗原 的识别和呈递 ,并激 活 CD4 、CD8 T 细胞,调控免疫应答发生,在感染和抗肿瘤免疫中发 挥重要作用。 近年来 ,随着 DCs 疫苗在抗肿瘤免疫 中的临床 应用 ,CD1 1C 靶向疫苗也逐渐在动物实验 中开展 ,并 显示出潜在的抗瘤效应 ,这将为 DCs ...