答:Gr-1单抗通常认为是粒细胞标记,但实际上,它既可结合Ly-6G也可结合Ly-6C。大多数 Gr1+ CD11b- 细胞是 Ly6C+ LyG-,Ly6C可表达在浆细胞、部分粒细胞和T 细胞(包括记忆 T 细胞)表达。所以Gr1+ CD11b-细胞可能CD8是阳性的,如果补做CD8是阳性的...
肿瘤微环境中F480CD11bGr1单核细胞活化机制的研究 华中科技大学 博士学位论文 肿瘤微环境中F4/80+CD11b+Gr-1+单核细胞活化机制的研究 姓名:*** 申请学位级别:博士 专业:生物化学与分子生物学 指导教师:**化 2010-05华中科技大学同济医学院博士研究生学位论文 +...
结果慢性束缚心理应激导致小鼠骨髓中CD11b~+Gr1~+细胞的子聚集,细胞亚群主要为Ly6G~+Ly6Clow的不成熟中性粒细胞,抑制了脂多糖(LPS)诱导下巨噬细胞产生IL-6/TNF-α,并抑制了T细胞的增殖。结论慢性束缚心理应激诱导小鼠CD11b~+Gr1~+髓系细胞的聚集,对体内免疫细胞发挥抑制作用。doi:10.3969/j.issn.1000-1905.2018...
《与Gr1+CD11b+髓系抑制细胞分化和功能有关的微小RNA研究》是依托南开大学，由杨荣存担任项目负责人的面上项目。中文摘要 Gr1+CD11b+髓系抑制细胞可由肿瘤与一些感染因素如病毒、细菌和寄生虫等诱导而大量产生,在产生免疫抑制、引导免疫逃逸过程中发挥着重要作用。研究免疫髓系抑制性细胞的关键在于搞清免疫髓...
采用小鼠4T1乳腺癌模型观察MSC通过CD11b+Gr1+细胞对肿瘤生长的影响.结果 MSC能够促进骨髓中CD11b+Gr1+细胞的存活和生成,同时可诱导正常小鼠骨髓中CD11b+Gr1+细胞对T细胞的抑制作用.动物实验结果显示,MSC处理后的骨髓CD11b+Gr1+细胞可以促进肿瘤的生长,加速小鼠的死亡.结论 MSC可以通过促进骨髓来源的CD11b+Gr1+细胞...
Gr1(int)CD11b(+) cells are called myeloid-derived suppressor cells (MDSC) and play a major role in regulation of inflammation in many pathological conditions. Although MDSC have been described primarily in cancer their function in tuberculosis remains unknown. During M. tuberculosis infection it is...
Studies have shown that bone marrow-derived cells play an important role in tumor recurrence after chemotherapy and radiotherapy. In this study, we examined the relationship between the accumulation of Gr-1+CD11b+ cells and tumor recurrence after irradia
The CD11b+ Gr1dim cells have never described previously and termed CD11b+ Gr1dim tolerogenic dendritic cell-like cells (CD11b+ Gr1dim tolDC-LCs). Th17 cells, ILC1s and ILC3s in the inflamed lung produced GM-CSF, which may expand CD11b+ Gr1dim tolDC-LCs in vivo. Furthermore, adoptive...
Easily and efficiently isolate highly purified mouse myeloid-derived suppressor cells (MDSCs) (CD11b+Gr1+) from mouse splenocytes, bone marrow, or peripheral blood samples by immunomagnetic negative selection, with the EasySep™ Mouse MDSC (CD11b+Gr1+) Isolation Kit. Widely used in published ...