Here, we describe a unique type of APC, Gr1−/lowCD11b−/low cells with a granularity and size characteristic of myeloid cells and with the ability to present Ag for crosspresentation. These cells constitutively express MHCII and the costimulatory molecules, CD80, CD86, and CD40. They do...
Gr1(+)CD11b(+) cells expressed high levels of arginase-1, and IL-17, additional markers of myeloid derived suppressor cells. We then sorted the Gr1(hi) and Gr1(int) populations from M. tuberculosis infected NOS-/- mice and placed the sorted both Gr1(int) populations at different ratios ...
答:Gr-1单抗通常认为是粒细胞标记,但实际上,它既可结合Ly-6G也可结合Ly-6C。大多数 Gr1+ CD11b- 细胞是 Ly6C+ LyG-,Ly6C可表达在浆细胞、部分粒细胞和T 细胞(包括记忆 T 细胞)表达。所以Gr1+ CD11b-细胞可能CD8是阳性的,如果补做CD8是阳性的...
Gr-1(+) cells could be found on the edges of necrotic lung lesions in NOS2-/-, RAG-/-, and C3HeB/FeJ, but were absent in wild-type mice. Both populations of Gr1(+)CD11b(+) cells expressed high levels of arginase-1, and IL-17, additional markers of myeloid derived suppressor ...
Metastasis is the major cause of death from breast cancer. Colonization and adaption of metastatic cells in distant organs is a rate-limiting step of the cancer spreading. The underlying mechanisms responsible for the colonization of breast cancer to lun
Furthermore, adoptive transfer of CD11b+ Gr1dim tolDC-LCs significantly suppressed the progression of ILD in SKG mice.We identified a unique suppressive myeloid cells termed CD11b+ Gr1dim tolDC-LCs, which were differentiated from M-MDSCs, in ILD of SKG mice. This article is protected by ...
The cells were also examined for the expression of F4/80, which is not expressed by neutrophils.10,11 Although the neu- trophils were F4/80 − , the Gr1int cells were F4/80 + . Collectively, the features of the Gr1int cells resembled those of myeloid- derived suppressor cells (MDSCs...
We were led to conclude that WBI can significantly decrease the accumulation of CD11b+Gr-1+cells in the spleen, reduce the infiltration of Gr1+CD11b+ cells in the tumor and finally delay the tumor re-growth after irradiation. Elimination of CD11b+ myelomonocytic cells-derived neovasculature by...
Recruitment of a myeloid cell subset (CD11b/Gr1mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis* Liver metastasis from colorectal cancer is a leading cause of cancer mortality. Myeloid cells play pivotal roles in the metastatic process, but their prome... - 《...
用溴脱氧尿嘧啶核苷一酶联免疫吸附实验(t3rdUElisa)测定青年鼠、老年鼠CDllb+GR1+MDSCs 对T细胞增殖的影响.通过Transwcll小室共培养实验及实时荧光定量PCR法检测青年 鼠、老年鼠CDllb+GR11MDSCs免疫抑制功能的差异。结果与青年鼠比较,老年鼠 MDSCs能明显抑制T ...