AIH患者肝内IL-15和TGF-β表达水平显著升高,且肝细胞广泛表达CD103配体- E-钙黏蛋白(E-cadherin),这些因素可能有助于CD8+ TRM细胞的分化和驻留。经过免疫治疗后,AIH患者肝内CD8+ TRM细胞数量显著下降。糖皮质激素可以通过直接下调CD8+ TRM细胞Blimp1的表达,从而抑制CD8+ TRM细胞的体外扩增。 该研究证实了CD69+...
Although CD103 cells were weaker effectors on a per cell basis than CD103+ cells following T-cell receptor or interleukin-15 stimulation, they remained the major CD69+CD8+ effector population in the liver, surviving with less cell death. HIF-2α inhibitor or knockdown suppressed the effector ...
Previous work from our laboratory has demonstrated in vivo persistence of CD103+CD69+brain resident memory CD8+T‐cells (bTRM) following viral infection, and that the PD‐1: PD‐L1 pathway promotes development of these TRMcells within the brain. Although glial cells express low basal levels of...
Whilst epithelial CD8(+) TRM cells co-express CD69 and CD103, CD103(-) memory cells have been described in ... SL Park,LK Mackay,T Gebhardt - 《Immunology & Cell Biology》 被引量: 7发表: 2016年 A case of CD8+ primary cutaneous peripheral T‐cell lymphoma arising from tissue‐...
Compared to healthy controls, the absolute number of CD8+ T cells in the intestinal tissues of aGVHD patients was significantly increased(Figure D), while the absolute number and proportion of CD8+CD69+CD103+ TRM cells were significantly decreased (P<0.0001)(Figure E),. Furthermore, patients ...
MCC950 also suppressed the maturation and functional capabilities of CD8+CD103+ T cells in a manner reliant on inflammasome activity in vitro. IL-1β promoted the expression of TGF-βRII in CD8+ T cells via the NF-κB pathway. Conclusions NLRP3 inflammasome activity in renal CD8+CD69+CD...
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