Tissue-resident memory T cells (TRM cells) are crucial mediators of adaptive immunity in nonlymphoid tissues. However, the functional heterogeneity and pathogenic roles of CD4+ TRM cells that reside within chronic inflammatory lesions remain unknown. We found that CD69hiCD103lo CD4+ TRM cells ...
近期,美国东北大学药学系Mansoor Amiji团队在《Journal of Controlled Release》杂志第345期上发表题为“Systemic nano-delivery of low-dose STING agonist targeted to CD103+dendritic cells for cancer immunotherapy”的研究性论文,报道...
ARTICLES nature publishing group CD103 À CD11b þ dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin SM Atif1, S Uematsu2, S Akira2 and SJ McSorley1 Toll-like receptor 5 (TLR5) has been widely studied in an inflammatory context, but the effect of...
Here we found that CD4+ T cells are important for the formation of functional lung-resident CD8+ T cells after influenza virus infection. In the absence of CD4+ T cells, CD8+ T cells displayed reduced expression of CD103 (Itgae), were mislocalized away from airway epithelia, and ...
Tissue-resident memory T cells (TRM cells) are crucial mediators of adaptive immunity in nonlymphoid tissues. However, the functional heterogeneity and pathogenic roles of CD4+ TRM cells that reside within chronic inflammatory lesions remain unknown. We found that CD69hiCD103lo CD4+ TRM cells...
CD103和CD39阳性细胞可能塑造适合B细胞抗肿瘤活性的肿瘤微环境,可以作为肿瘤特异性CD8 T细胞的有用标志物,并可用于开发靶向免疫疗法。 番外 另一篇相关文献 Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade(doi: 10.1136/jitc-2020-002231)...
Clustering analysis of the proteomic data revealed a signature driven by checkpoint marker expression on CD103CD4 T cells that could potentially be predictive of CTCs and targets of therapy. 展开 关键词: Aneuploidy CCR5 CTLA-4 Cancer marker Circulating tumor cell High parameter flow cytometry LAG3 ...
CD103和CD39阳性细胞可能塑造适合B细胞抗肿瘤活性的肿瘤微环境,可以作为肿瘤特异性CD8 T细胞的有用标志物,并可用于开发靶向免疫疗法。 番外 另一篇相关文献 Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade(doi: 10.1136/jitc-2020-002231)...
T细 胞百分率为(7.47±1.30)%,明显低于银屑病非皮损区(P<0.05)。银屑病患者皮损中,CD103 + T的表达 与PASI值正相关(P<0.05)。结论:真皮中CD103 + T细胞可能与银屑病的发病及严重程度有关。 [关键词]银屑病;CD103 + T细胞;免疫组化 ExpressionofCD103 ...
DC可诱导肠粘膜调节性T细胞CD4 + Foxp3 + Treg的产生;在肠系膜淋巴结(Mesentericlymphnodes,MLN)中,迁移性CD103 + DC不仅可影响肠道T细胞和B细胞表面归巢分子的表达,而且能够诱导Foxp3 + Treg的产生,Annacker等研究表明当存在CD103 + DC时,Treg细胞可抑制T细胞介导的结肠炎。当机体处于病理状态时,肠道上皮发生炎...