Positive staining (disease):adenomyosis of endometrium, preB ALL (75%), CML in blast crisis (90%), colonic carcinoma, dermatofibroma, dermatofibrosarcoma, endometrial adenocarcinoma (may be present in desmoplastic stroma), endometrial stromal tumors, follicular center cell lymphomas, gastric carcinoma,...
cd123在cd34+定向祖细胞上表达(taussig,d.c.等(2005)“hematopoieticstemcellsexpressmultiplemyeloidmarkers:implicationsfortheoriginandtargetedtherapyofacutemyeloidleukemia,”blood106:4086-4092),但不通过cd34+/cd38-正常造血干细胞表达。cd123通过嗜碱性粒细胞、肥大细胞、浆细胞样树突状细胞表达,通过单核细胞、巨噬细...
CDCP1还在其他多种癌症中有高表达,如喉癌 [24]、宫颈癌 [25]、肾癌 [13]、肝细胞癌 [26]、慢性髓系白血病(CML)[27]和急性髓系白血病(AML) [28-29]等。以喉癌为例,一项研究检测了喉癌组织和癌旁组织中的MMP-9、CDCP1和NLK的表达。结果发现,喉癌组织中这三种蛋白的表达都高于癌旁组织,尤其是NLK。NLK是...
This study evaluated the therapeutic potential of miltefosine (MFS), a phospholipid analogue, for treating leukopenia. In vitro studies using HL60 and NB4 cells revealed that MFS effectively promoted neutrophil differentiation and function, evidenced by the upregulation of surface markers CD11b, CD11c,...
Little is known about the function and phenotype of leukemic stem cells (LSCs) in chronic myeloid leukemia (CML) or about specific markers that discriminat... M Culen,M Borsky,V Nemethova,... - 《Oncotarget》 被引量: 5发表: 2016年 ...
‘lymphoid’-associated markers. For example, a proportion of ALL cases express CD13, CD33 and/orCD15. In most of these cases, the expression of an array of lymphoid-associated antigens and the rearrangement of Ig orTCRgenes strongly indicate a lymphoid origin. In a proportion of AML cases...
CD123在CD34+定向祖细胞上表达(Taussig,D.C.等(2005)“Hematopoietic Stem CellsExpress Multiple Myeloid Markers:Implications For The Origin And TargetedTherapy Of Acute Myeloid Leukemia,”Blood 106:4086-4092),但不通过CD34+/CD38-正常造血干细胞表达。CD123通过嗜碱性粒细胞、肥大细胞、浆细胞样树突状细胞...
Altogether these data show that the CD70-CD27 axis is tightly regulated during hematopoietic cell development showing either CD70 or CD27 expression but generally never co-expression of both markers. In addition, interaction of these costimulatory molecules orchestrates important signaling pathways on ma...
在进一步优选的实施方式中,癌症是白血病,并且选自:急性骨髓性白血病(aml);慢性骨髓性白血病(cml);急性淋巴细胞性白血病(all);慢性淋巴细胞性白血病(cll)。 术语“受试者”旨在包括活的生物体。受试者的实例包括哺乳动物,例如人、犬、牛、马、猪、绵羊、山羊、猫、小鼠、兔、大鼠和转基因非人动物。在本发明的优选...
However, CD25 cannot be considered a fully reliable marker for Tregs because it can also be upregulated transiently in activated human Tconv cells,9requiring the inclusion of additional markers for better identification of the Tregs. Classically, the “master regulator” of development and suppressive...