Although CXCR3+ CCR6- classical Th1 CD4+ T cells are thought to be essential for acute cellular immunity, such as antiviral responses, the details of Th1-type CD4+ T cells required for anti-tumor immunity as a long-term chronic T cell immune responses over years remain unclear. We ...
CCR6 regulates CD4(+) T-cell-mediated acute graft-versus-host disease responses CCR6 regulates CD4ϩ T-cell-mediated acute graft-versus-host disease responses. Blood 106: 18 -26.CCR6regulates CD4+T-cell-mediated acute graft-... R Varona,V Cadenas,L Gómez,... - 《Blood》 被引量: ...
6 Whereas Tr1 cells seem to acquire their suppressor status in the periphery by polarization of naive T cells, Treg cells are described as “born” suppressors. Although some recent data indicate that at least to some extent Treg cells can derive also from the CD25-CD4+ T-cell subset,7 ...
ARTICLES The loss of CCR6 þ and CD161 þ CD4 þ T-cell homeostasis contributes to disease progression in SIV-infected rhesus macaques CS McGary1, X Alvarez2, S Harrington3, B Cervasi1, ES Ryan1, RI Iriele1, S Paganini1, JL Harper1, K Easley4, G Silvestri1,5, AA Ansari5, ...
如图3所示,该团队对骨转移中功能失调的细胞毒性T淋巴细胞(CTL )亚群的详细分析揭示了预期的亚群,CD4+ TH 和 Tregs 和 CTL,以及 NK 和 NKT 细胞。其中CTL 可以进一步细分为两种亚型:表达 CTL-1 的效应 T 细胞基因,例如 KLRG1、GZMK 和其他细胞毒性介质;而 CTL-2 的特征是效应/记忆样转录谱,包括 IL7R 和 ...
T cellsCerebrospinal fluidMultiple sclerosisCCR6Th1Th17GM-CSFConsiderable attention has been given to CCR6+ IL-17-secreting CD4+ T cells (Th17) in the pathology of a number of autoimmune diseases including multiple sclerosis (MS). However, other Th subsets also play important pathogenic roles, ...
CCR6 miRNAs Regulatory T cell Microarray摘要 Backgroud. CCR6(+) CD4(+) regulatory T cells (CCR6(+) Tregs), a distinct Tregs subset, played an important role in various immune diseases. Recent evidence showed that microRNAs (miRNAs) are vital regulators in the function of immune cells. ...
有63 个独特的克隆型在特发性CP的CD8+ cytotoxic T-cell clusters中发现了共享的克隆型。CCR6+ CD4+ T细胞与Th1细胞之间的克隆型重叠最高,有23个共享克隆型,这些重叠主要发生在遗传性CP中。这些共享的TCR克隆型阐明了不同t细胞亚型之间的独特相互作用和每个CP组的克隆动力学。
TregsorCD4CD25CCR6。regulatoryTcells(CCR6’Tregs).Tumorgrowthandsurvivalof4T1bearingmice wereobserved.Theproliferation,IFN一 production,andgranzymeBexpressionofCD8TcellswereexaminedbyFACS. Results:BothCCR6 TregsandCCR6’TregsexpressedhighlevelsofFoxp3.ThetumorsinCCR6 ...
有63 个独特的克隆型在特发性CP的CD8+ cytotoxic T-cell clusters中发现了共享的克隆型。CCR6+ CD4+ T细胞与Th1细胞之间的克隆型重叠最高,有23个共享克隆型,这些重叠主要发生在遗传性CP中。这些共享的TCR克隆型阐明了不同t细胞亚型之间的独特相互作用和每个CP组的克隆动力学。