plants Article Genome-Wide and Comprehensive Analysis of the Multiple Stress-Related CAF1 (CCR4-Associated Factor 1) Family and Its Expression in Poplar Pu Wang, Lingling Li, Hui Wei, Weibo Sun, Peijun Zhou, Sheng Zhu, Dawei Li and Qiang Zhuge * Co-Innovation Center...
Angel homolog 2 (Ccr4d), one of two Angel orthologues encoded in thehuman genome, associates with a distant cousin of Caf1, Caf1z. The complex has deadenylase activity of unknownbiological function[30]. Nocturnin may be associated with other subunits of the Ccr4–Not complex, again in the...
Although there does not appear to be a direct homolog of PARN in yeast, Ccr4p/Caf1p and Pan2p/Pan3p are all highly conserved among eukaryotes. This implies that eukaryotic cells will contain at least two, and likely multiple, distinct deadenylases. This raises the possibility that ...
The third non-catalytic module assembles on a central region of NOT1 close to the catalytic module, and includes the NOT9 subunit, the human homolog of yeast Caf4032,33. The RING-type E3 ligase NOT4 interacts via NOT9/Caf40 with the CCR4-NOT complex, though it is stably associated ...
This indicates that NOT1 MIF4G-C domains are likely to be structurally closely related and that the Ct NOT1 MIF4G-C domain can be considered a close structural homolog and representative of the Hs MIF4G-C domain. Having established that the crystallized Ct domain adopts a MIF4G-like fold ...