plants Article Genome-Wide and Comprehensive Analysis of the Multiple Stress-Related CAF1 (CCR4-Associated Factor 1) Family and Its Expression in Poplar Pu Wang, Lingling Li, Hui Wei, Weibo Sun, Peijun Zhou, Sheng Zhu, Dawei Li and Qiang Zhuge * Co-Innovation Center...
Angel homolog 2 (Ccr4d), one of two Angel orthologues encoded in thehuman genome, associates with a distant cousin of Caf1, Caf1z. The complex has deadenylase activity of unknownbiological function[30]. Nocturnin may be associated with other subunits of the Ccr4–Not complex, again in the...
The third non-catalytic module assembles on a central region of NOT1 close to the catalytic module, and includes the NOT9 subunit, the human homolog of yeast Caf4032,33. The RING-type E3 ligase NOT4 interacts via NOT9/Caf40 with the CCR4-NOT complex, though it is stably associated ...
First, both Ccr4p and its associated factor, Caf1p, have nuclease domains. Ccr4p belongs to a magnesium-dependent endonuclease-related family of nucleases (Dlakic, 2000; C. D., unpublished observations). Caf1p homologs in mammalian cells and C. elegans are members of the RNaseD family of ...
This indicates that NOT1 MIF4G-C domains are likely to be structurally closely related and that the Ct NOT1 MIF4G-C domain can be considered a close structural homolog and representative of the Hs MIF4G-C domain. Having established that the crystallized Ct domain adopts a MIF4G-like fold ...