O. et al. Essential role of CCR2 in neutrophil tissue infiltration and multiple organ dysfunction in sepsis. Am. J. Respir. Crit. Care. Med. 183, 234–242 (2011). 37. Maus, U. et al. The role of CC chemokine receptor 2 in alveolar monocyte and neutrophil immigration in intact mice...
Several studies have shown that the levels of MCP-1 are increased in animal models of sepsis [10], [39]. In our study, we have found a decrease in the expression of this chemokine in CCR2 KO mice, and we suggest that this decrease is due to a negative feedback mechanism in which ...
SepsisHMGB1CCR2MCP-1GlycyrrhizicacidOur aim was to investigate \\\{CCR2\\\} and \\\{HMGB1\\\} involvement in a murine model of endotoxic shock. We used C57BL/6 \\\{CCR2\\\} knockout (KO) mice and wild-type (WT) littermates to establish an optimal dose of LPS. \\\{CCR2\...