CYTOTOXICITY TARGETING CHIMERAS FOR CCR2-EXPRESSING CELLSThe present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an ...
production of C-C motif chemokine ligand 2 (CCL2) through activation of nuclear factor-[kappa]B (NF-[kappa]B) and signal transduction and activator of transcription 3 (Stat3), which mediates migration of C-C chemokine receptor type 2 (CCR2)-expressing inflammatory myeloid cells into the ...
Toll-like receptor 4 stimulation had no effect on the already high frequencies of IL-6-producing cells among any subset (Figure 5d). Given that the CCR2-expressing CD103 À CD11b þ DCs did not show any difference in their ability to prime Th1 responses, these findings indicate that ...
The lowest intensity was obtained from T cells in LNs (MFI: <70). These results indicate heterogeneous CCR2 expression among tissues and subsets, both in terms of the frequency of cells with receptor expression, as well as the intensity of expression in receptor-expressing cells. Figure 3 ...
The ability of the CCR2-targeting PEG-DSPE lipid micelles to more efficiently reduce the number of inflammatory monocytes in both the heart and the spleen is likely due to their ability to specifically bind to CCR2-expressing cells. There are several limitations of our study. First, our in ...
CCR2-expressing cells had increased trafficking to the tumor and increased efficacy [79] (Fig. 2D). Increased CAR T-cell homing and antitumor efficacy were also seen in GD2-targeted CAR T cells in an in vivo model of neuroblastoma [80], as well as in TCR-transduced T cells in an in ...
This leads to the recruitment of immune cells expressing CCR2, promoting brain metastasis outgrowth after cancer cell extravasation [95,170]. CCL2 produced via activated astrocytes enhance brain metastasis via promoting transmigration in CCR2 dependent manner [171]. The proliferation of metastatic cells...
Arrows indicate the co-expressing cells. **P < 0.01. Two-Way ANOVA followed by post-hoc Bonferroni test (n = 4 mice/group). Data are expressed as mean ± SEM Full size image CCR2 is co-labeled with CGRP and IB4 in the superficial layer of spinal cord In order to ...
E UMAP visualization of the distribution of CCR2 and MHC-II expressing cells in the macrophage clusters. F Visualization of CD68 + (green) and CCR2 + (red) cells in the heart 4 weeks after MI. Scale bar represents 20 μm Full size image We then analysed the overall ...
Dystrophinopathy, a common neuromuscular disorder caused by the absence of dystrophin, currently lacks effective treatments. Systemic transplantation of adipose-derived stem cells (ADSCs) is a promising treatment approach, but its low efficacy remains a