ccr2(c-c motif chemokine receptor 2,cc趋化因子受体2)是趋化因子配体ccl2的受体,其在髓系抑制性细胞(mdscs)表面高表达。有报道认为ccr2信号似乎通过破坏树突状细胞的成熟来实现免疫抑制,树突状细胞是最重要的抗原呈递细胞,对免疫应答的启动至关重要。与表达ccr2的癌细胞相比,由不表达ccr2的细胞所产生的肿瘤中...
趋化因子CCL2及其受体CCR2在募集TAMs参与肿瘤侵袭转移发挥重要作用,CCL2通过募集TAM浸润肿瘤组织,分泌VEGF、TGF-β、TNF-α等细胞因子,促进肿瘤细胞生长与血管生成,同时还分泌基质金属蛋白酶MMP2、MMP9,参与细胞外基质破坏与重构,促进肿瘤细胞侵袭和转移。有研究报道,抗C...
Using a toxin-mediated ablation strategy to target CCR2-expressing cells, we show that these monocytic MDSCs regulate entry of activated CD8 T cells into the tumor site, thereby limiting the efficacy of immunotherapy. Our results argue that therapeutic targeting of monocytic MDSCs would enhance ...
CCL2与CCR2相互作用,维持肿瘤细胞生长和增殖;CCL2可招募CCR2+TAMs、MDSCs和Th2细胞,创造利于肿瘤进展的免疫抑制微环境;TAM分泌的VEGF通过与CCR2+血管内皮细胞的相互作用促进肿瘤血管生成;CCL2促进单核细胞分化为MAMs以及肿瘤转移前生态位的形成,加速转移性肿瘤细胞的定植和生长。 图3 CCL2-CCR2轴及其调控的信号转...
and is prognostic for hepatocellular carcinoma patients30. Interactions between CCL2/CCR2 have been shown to recruit immunosuppressive cells such as myeloid-derived suppressor (MDSC) cells and metastasis-promoting monocytes31,32. There is also compelling evidence for the targeting of CCL2/CCR2 in ...
Myeloid Lineage Markers Myeloid-derived Suppressor Cells (MDSC) Obesity Platelet Cytokine and Growth Factor Receptors Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) T Cell Migration/Adhesion Uptake of Amyloid beta by Macrophages
ccr2+mdscs具有免疫抑制功能。mdscs在肿瘤抑制免疫反应的能力中起关键作用。此种抑制的另一个关键因素是免疫检查点的激活,进而限制了t细胞的活性以及向肿瘤的浸润。免疫检查点是指免疫系统中对于维持自我耐受和控制周围组织的免疫反应以最大程度地降低附带组织损害至关重要的抑制途径。
此外,在肿瘤微环境中高表达CCR2的M-MDSC通过抑制CD 8 + T淋巴细胞在肿瘤部位的聚集,削弱了免疫治疗的效果 [ 27 ] 。在多种其他肿瘤小鼠模型中,阻断CCL2-CCR2轴可以减少MDSC的数量并提高抗肿瘤疗效 [ 28 ]。MDSC在促进肿瘤进展方面发挥着重要的作用,目前尚无在卵巢癌中阻断CCL2-CCR2轴是否可以提高抗肿瘤...
Law et al.2020). Apparently functional specialization of MDSCs depends upon the CCL2–CCR2 pathway. It has been observed that the CCL2 is the key player in case of colorectal cancer, and it promotes the growth of cancer and also increase the function and number of MDSCs. The stimulation...
Myeloid Lineage Markers Myeloid-derived Suppressor Cells (MDSC) Obesity Platelet Cytokine and Growth Factor Receptors Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) T Cell Migration/Adhesion Uptake of Amyloid beta by Macrophages