由于巨噬细胞FGF12具有调节肝纤维化进程的能力,作者首先假设FGF12的表达可以影响肝纤维化过程中巨噬细胞的表型转换。考虑到骨髓来源的Ly6C高表达巨噬细胞在损伤肝脏的巨噬细胞群中占主导地位,并且对HSC的激活至关重要。作者先在小鼠模型中检...
TBI 单核细胞/巨噬细胞上 Ly6C hi和Chil3共表达的验证 ✦ 在Chil3hi巨噬细胞中,Ly6c2被鉴定为差异表达基因(DEG),与其他亚群相比表达量高出2倍(见图S7)。这一发现出乎意料,因为Ly6C的高表达是促炎单核细胞的经典标志,而Chil3与抗炎的(IL-4)巨噬细胞...
CCR5 directs the mobilization of CD11b(+)Gr1(+)Ly6C(low) polymorphonuclear myeloid cells from the bone marrow to the blood to support tumor development[J]. Cell Rep, 2017,21(8):2212-2222. DOI: 10.1016/j.celrep.2017.10.104 . 返回引文位置Google Scholar 百度学术 万方数据 [12] Georgakis...
attraction of Ly6C monocytes, which makes B16F10 cells more likely to metastasis to the lung (van Deventer et al.2013). It has been demonstrated that CCL2 produced by melanoma cells attracts cytotoxic T lymphocytes by interacting to the CCR4 receptor on the lymphocytes (Zhang et al.2006). I...
图4显示了对ct26肿瘤分离出的m-mdsc细胞作直接设门,显示了ccr2的强表达。图a:对cd11b+群体上的活的cd45+ct26浸润细胞进行设门。图b:对lychi/ly6g-群体进行设门。图c:对ly6chi/ly6g-群体上同种型匹配的对照mab染色(左)作ccr2染色(右)的直方图覆盖。
G2 subset cells (CD64 À ) expressed CCR2 and Ly6C, the monocyte-related antigens, and were classified into CCR2high Ly6Clow (R1) and CCR2low Ly6Chigh (R2) two subsets (Figure 1b). Therefore, of the F4/ 80 þ CD11b þ cells in the cornea, only F4/80high CD11b þ ...
携带肿瘤的动物也显示出全身性的TAN增加(CD11b+, Gr1High, Ly6CLow和LY6GHigh),并且在临床前研究中,靶向TAN可以增加肿瘤浸润淋巴细胞(TIL)并改善对检测点阻断的反应。 作者先前的研究发现PDAC表达CCL2动员CCR2 +炎症巨噬细胞从骨髓肿...
CCR2+Ly6C+ monocytes and differentiated Lyve1− IMs engulf vaccinia virus particles and restrict viral dissemination. The antiviral function of CCR2+ monocytes is likely dependent on IFN-β signaling in AECIIs. We speculate that CCL2 and CCL7 produced by lung AECIIs upon VACVΔC7L infection ...
如所述的应用,具体特征为人参皂苷Rg1通过抑制由CCL2-CCR2信号通路介导的Ly6C hi 单核细胞趋化作用从而减少其中枢炎性浸润。 如所述的应用,具体特征为人参皂苷Rg1通过抑制由CCL2-CCR2信号通路抑制中枢炎症状态下小胶质细胞活化及神经元损伤从而缓解中枢疾病炎症状态。 如所述的应用,具体特征为人参皂苷Rg1缓解中枢炎...
et al. CCR2 deficiency impairs Ly6C(lo) and Ly6C(hi) monocyte responses in orientia tsutsugamushi infection. Front. Immunol. 12, 670219. https://doi.org/10.3389/fimmu.2021.670219 (2021). Article CAS PubMed PubMed Central Google Scholar Wang, Y. et al. CCR2 and CXCR4 regulate ...