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The mRNA microarray data derived from human tonsillar B cell populations provide strong evidence that CCR6+ LZ B cells form the precursors for MBCs in both human and mouse GCs. In addition, the specific transcripts differentially regulated during the process of MBC differentiation could provide insi...
We report that Th17 cells preferentially migrate to the intestine and associated lymphoid tissues, and CCR6 is the homing receptor important for Th17 cell migration to certain tissue microenvironments of the intestine such as Peyer's patches and other sites where its ligand CCL20 is expressed. We...
To investigate the molecular mechanisms of chemokine receptors in ligand recognition and signal transduction, two endogenous ligands, CCL2 and CCL11, were used to form G-protein-coupled CCR2 and CCR3 complexes. To obtain a stable CCL2–CCR2–Gi complex, the wild-type full-length human CCR2 ...
The human CCR5, a subfamily of G-protein-coupled, seven-transmembrane-domain cell-surface chemokine receptors that binds to beta;-chemokine, was heterologously expressed in fission yeast, Schizosaccharomyces pombe, through CCR5-GST fusion protein. The CCR5-GST fusion protein was driven by the full-...
WT and CCR6–/– mice were administered a 6-mm full-thickness skin wound on the dorsum. (a–c) Wound size was measured daily. Scale bars = 5 mm. (d) By flow cytometry, γδ T cells and Vγ4 T cells were enumerated from (e) wounds, (f) lymph nodes, and (g) blood. (h) ...
22 KEYB4 I/O IP 1 Line of the triangular keyboard matrix These lines form a small extra triangular keyboard matrix. (See Figure 7). This keyboard is scanned every 10 milliseconds. To scan the keyboard, the lines are made low - one at a time - and then the state of the other lines...
Giant congenital melanocytic nevi are brown-black lesions larger than 20 cm caused by benign proliferation of melanocytes. They either regress or progress in time in matters of thickness and size and may transform to malignancies. Here we report a twelve year old patient with giant melanocytic ...
aHotline weekly report Hotline weekly report[translate] aBased on information asymmetry, pecking order model requires full access to all funding choices: retained earnings, debt, and equity. 凭信息非对称,社会等级模型要求全部存取到所有资助选择: 保留的收入、债务和产权。[translate] ...