Ctrl, control group; CCl4, carbon tetrachloride treated group; H-MF, high dose of mangiferin (100 mg/kg). Full size image Discussion CCl4-induced liver fibrosis animals have been widely used as a model to simulate the pathogenesis of human liver fibrosis27. The current study demonstrated that...
Phase equilibria involving orientationally disordered (OD) and liquid phases of the two-component system between carbon tetrachloride (CCl4) and 2-methyl-2-bromomethane ((CH3)3CBr) have been determined by means of X-ray powder diffraction and thermal analysis techniques from 210 K up to the ...
Chemicals and biochemical reagents Carboxymethylcellulose sodium salt (CMC-Na), carbon tetrachloride (CCl4), olive oil, Tween 80, formaldehyde, ethanol, acetic acid, isopropanol and NH4OAC were purchased from Sinopharm Group Co., Ltd. (Shanghai, China). Acetonitrile and methanol (high-performance l...
Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4 Sun Myoung Kim, Ga Yeon Song, Aeri Shim, Jee Hyung Lee, Cheol Bin Eom, Cheng Liu, Yoon Mee Yang & Ekihiro Seki Experimental ...
FOXA2 modulates ER stress in hepatocytes during hepatic fibrogenesis. (a) A heat map diagram of 544 differentially expressed genes in hepatocytes between FOXA2f/fand FOXA2H-KOfibrotic mice, which were identified by high-throughput RNA-sequence analysis. (b) Histogram of KEGG classifications of as...
Among these chemicals, carbon tetrachloride (CCl4) is a highly toxic compound widely used in experimental research to study liver injury [4]. In the liver, cytochrome P450 enzymes convert CCl4 into free radicals such as trichloromethyl radical (•CCl3) and peroxy trichloromethyl radical (•...
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the LC-MS metabolomics technique was applied to explore the changes in metabolites in rats with liver fibrosis after TACS administration and the metabolic pathway of significant enrichment. Furthermore, we drew a comprehensive metabolic network diagram to reveal the relationship between differential metabol...