另外,有报道认为CCL3对T淋巴细胞、NK细胞、细胞毒性T细胞、B细胞、嗜碱性粒细胞和嗜酸性粒细胞有不同的趋化和促粘附作用。CCL3已被确定为是一种干细胞抑制剂(SCI),可抑制造血祖细胞在体外和体内的增殖。CCL3、CCL4和RANTES被认为是由CD8+T细胞产生的重要的HIV抑制因子。
The macrophage inflammatory proteins -1 alpha and -1 beta were originally co-purified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP-1 alpha refers to the products of several independently cloned cDNAs, including LD78, pL78, pAT464, and GOS19. These cDNAs...
As members of the chemokine family, macrophage inflammatory protein 1 alpha (MIP-1alpha) and MIP-1beta are unique in that they both consist of non-allelic isoforms encoded by different genes, namely chemokine (C-C motif) ligand 3 (CCL3), CCL4, CCL3-like 1 (CCL3L1) and CCL4L1. The ...
CCL3, also known as macrophage inflammatory protein 1 alpha (MIP-1 alpha ) and LD78, is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. Chemokines comprise a large family of small secreted proteins that are involved in immune and inflammatory...
CCL3, also known as macrophage inflammatory protein 1 alpha (MIP-1 alpha ) and LD78, is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. Chemokines comprise a large family of small secreted proteins that are involved in immune and inflammatory...
MacrophageActivityAltersthe InflammatoryProcessinNecrotizing Enterocolitis.JournalofCytokineBiology .2017,全文. XiYuanetal.CCL3aggravates intestinaldamageinNECbypromoting macrophagechemotaxisandM1macrophage polarization.PediatricResearch.2022,全文. JianiWangetal..Therapeutic MechanismofMacrophageInflammatory Protein1α...
CCL3, also known as MIP-1 alpha (Macrophage Inflammatory Protein 1 alpha), is a member of the CC- subfamily of chemokines and is most closely related to CCL4, or MIP-1 beta. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation....
15,18 This BCR- and NLC-dependent induction of CCL3 and CCL4 was sensitive to inhibition of BCR signaling, using a spleen tyrosine kinase inhibitor.21,22 CCL3 and CCL4, previously called macrophage inflammatory protein-1α (MIP-1α) and MIP-1β are chemokines of the CC subfamily and ...
CCL3, also known as MIP-1 alpha (Macrophage Inflammatory Protein 1 alpha), is a member of the CC- subfamily of chemokines and is most closely related to CCL4, or MIP-1 beta. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation. While both CCL3...
When compared to freshlyisolated blood CLL B cells, we found that CLL B cells co-culturedfor 14 days with NLC displayed high level expression of twoT cell chemoattractants, macrophage inflammatory protein-1aand b (MIP-1 a, MIP-1b, also called CCL3 and CCL4). CCL3 andCCL4 expression ...