Alanine substitutions of polar and nonpolar residues in the amino-terminal domain of CCR5 differently impair entry of macrophage- and dualtropic isolates of human immunodeficiency virus type 1. J. Virol. 72, 3464–3468 (1998). 30. Kondru, R. et al. Molecular interactions of CCR5 with major ...
These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g.,...
infrequently, its backbone carbonyl forms a hydrogen bond with the charged N-terminal of CCR5 residue Met1. CCL5 residues Cys10 and Cys11 are enveloped between and interact with, the non-polar side chain moieties of CCR5 residues Met1, Tys3 (sulfated tyrosine 3), Gln21, Asn24, Lys171, ...