Even at regular landfills, leachate with complex components can still form during long-term operation and pose a threat to the environment. There were 1259 organic compounds detected from rivers and wells around the landfill reported by the U.S. Environmental Protection Agency (USEPA) in 1976 (...
Human iPSCs secrete laminin 511/521, one of the most important functional basement membrane components, and they can be maintained on human laminin 511 and 521 in defined culture conditions. However, large-scale production of puri- fied or recombinant laminin 511 and 521 is difficult and ...
However, the supernatant represents a crude mixture, and the involvement of other components such as exotoxins A or B cannot be excluded. Nevertheless, flagellin from Salmonella has been shown specifically to stimulate CCL20 secretion by IECs [16]. This leads to the recruitment of CCR6-...
Synovial tissues from seven rheumatoid arthritis (RA) patients were used for the ultrastructural investigation of capillary cellular components and basemen... T Matsubara,M Velvart,BF Odermatt,... - 《Rheumatology International》 被引量: 47发表: 1983年 The role of leukocyte-stromal interactions in...
CCL2 is an inflammatory cytokine that regulates macrophage activity and is implicated in increased mammographic density and early breast tumorigenesis. The role of CCL2 in mediating stromal interactions that contribute to breast tumorigenesis has yet to
Background: Age-related macular degeneration (AMD) is the most common cause of progressive and irreversible blindness in developed countries. Although the pathogenesis is not fully understood, AMD is a multifactorial pathology with an accumulation of inflammatory components and macrophages and a strong ...
Astrocytes have their end feet in close contact with the basal membrane, while their other projections extend further into the brain parenchyma and interact with other cells and components of the nervous tissue [4]. Pericytes support and maintain the endothelium through both paracrine signaling and ...
Inflamed macrophages adopt a more active and complex role that involves Fe sequestration (ferroportin SLC40A1), cytokinesis (septin SEEP1), expression of complement components (C1QA, C1QB, C1QC), innate immune defense by enzymes (LYZ), and suppression of the opposing phenotype of tolerogenic (...
The chemokine CCL18 is produced in cells of the myelomonocytic lineage and represents one of the most highly expressed chemokines in lesional skin and serum of atopic dermatitis patients. We investigated the role of histamine in CCL18 production in human
Tumor-associated macrophages (TAMs) are one of the main components of the breast TME, representing up to 50% of the tumor mass [6]. They derive from circulating monocytes, and their infiltration in the TME is associated with a poor prognosis. Indeed, TAMs promote tumor growth, progression, ...