ACEI/ARB主要通过作用于肾素-血管紧张素-醛固酮系统(renin-angiotensin-aldosterone system,RAAS)中血管紧张素转换酶(angiotensin-converting enzyme,ACE)以及ACE2两条途径发挥作用。在经典的ACE-血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)-血管紧张素...
Combination therapy with an ace-inhibitor (acei)/calcium channel blocker (ccb) for hypertensive patients non-responsive to ace-inhibitor monotherapy: an efficacy and safety trialP-187 Key Words: Amlodipine, Benazepril, Combination Therapydoi:10.1016/j.amjhyper.2004.03.262S CHRYSANT...
Dual blockade of the renin-angiotensin-aldosterone system: beyond the ACE inhibitor and angiotensin-II receptor blocker combination. The renin--system (RAAS), an important regulator of blood pressure as well as fluid and electrolyte balance, plays an important role in the pathophysiology... AS Bomb...
ACEI/ARB主要通过作用于肾素-血管紧张素-醛固酮系统(renin-angiotensin-aldosterone system,RAAS)中血管紧张素转换酶(angiotensin-converting enzyme,ACE)以及ACE2两条途径发挥作用。在经典的ACE-血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)-血管紧张素受体(主要为1型受体,angiotensin type 1 receptor,AT1R)途径中,ACEI(或ARB)通...
Angiotensin-converting enzyme inhibitor/calcium channel blocker(ACEI/CCB) combination drugs are used to treathigh blood pressure.Hypertensionis one of the major risk factors forcardiovascular disease, kidney disease, andstroke. ACEIs work by inhibiting angiotensin-converting enzyme (ACE). This enzyme conv...
peripheralvasodilationandreduceBPbutactivatetheSNSandincreasereninactivityandthusangiotensinIIproduction.CCBsstimulatetheRAAS,therebyenhancingtheeffectivenessofACEinhibitorsinawidevarietyofpatients.TheadditionofACEinhibitorstoCCBsincreaseBPreductioncomparedwithplaceboinclinicaltrials.CombinationofCCBsandACEinhibitorshavebeen...
6、particularly for the combination of a diuretic+ an ACE inhibitor or an ARB or a CCB, and in recent large-scale trials for the ACE inhibitor/CCB combination. The ARB/CCB combination also appears to be rational and effective. These combinations can thus be recommended for priority use.,2009...
26、otal patients,Comparisons of ACE-inhibitor-based therapy with calcium-antagonist-based therapy,BPLT: Lancet 2000; 355:1955,0.51.02.0,Relative risk FavorsFavors ACE-1calcium antagonists,BPLT协作研究第一轮分析的结论,证实ACEIs和长效CCBs降压治疗能显著减少 CVD事件发生与CVD死亡率 积极降压治疗对减少CVD...
Reduced cardiovascular morbidity and mortality in hypertensive diabetic patients on first-line therapy with an ACE inhibitor compared with a diuretic/β-blocker-based treatment regimen. Diabetes Care 2001; 24: 2091–2096. Article CAS Google Scholar Maggioni AP, Anand I, Gottlieb SO, Latini R, ...
ACE inhibitor if needed, allows for better blood-pressure control, fewer side effects such as new-onset diabetes, less add-on medication for better persistence with antihypertensive therapy, and last but not least, a greater reduction in morbidity and mortality than with beta blockers and ...