We found B7-H3 to be expressed on all sarcoma cells tested and expression on sarcoma patients correlated with decreased progression-free and overall survival. CC-3 was found to elicit robust T cell responses against multiple sarcoma subtypes, resulting in significant a...
HS-20093 是一种新型 B7-H3 靶向抗体药物偶联物 (ADC),由全人源化的 B7-H3 单抗与拓扑异构酶抑制剂(TOPOi)有效载荷共价连接而成,目前正在中国进行多项用于治疗肺癌、肉瘤、头颈癌及其他实体瘤的 Ⅰ 期和 Ⅱ 期临床研究。 HS...
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Unveiling Transcriptional Mechanisms of B7-H3 in Breast Cancer Stem Cells Through Proteomic Approaches. www.cell.com/iscience/fulltext/S2589-0042(25)00479-1
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