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Fig. 1: KDM5B is upregulated in Ewing sarcoma and is associated with poor prognosis. ABox plot ofKDM5BmRNA expression in GSE17674 between Ewing sarcoma samples and normal tissues.BKDM5B expression in Ewing sarcoma cell lines A673, SKNMC and RDES versus in normal cell line hMSC assessed ...
The equilibrium state of CCR5 is manipulated here toward either activation or inactivation by introduction of single amino acid substitutions in the transmembrane domains (TMs) 6 and 7. Insertion of a steric hindrance mutation in the center of TM7 (G286F in position VII:09/7.42) resulted in ...
(Pfr). Following conversion to the biologically active Pfr form, phytochromes translocate into the nucleus and interact with an important subfamily of bHLH transcription factors, the phytochrome interacting factors (PIFs). Their interaction leads to their phosphorylation, ubiquitination, and degradation via...
[232] Cremolini C,Loupakis F,Antoniotti C,et al.FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses...
修正手术可分为恢复性(reversal)手术(修正为正常解剖结构)、修改(conversion)手术(从一种术式修改为另一种术式)和修复(repair)手术(在原术式基础上进行修正,原术式不变)[22-23]。SG术后出现体重反弹或者减重不足时,可选择的修正手术术式相对较多,而...
IR分析显示游离的甲磺酸和和NaCMC反应得到一个复合物,化学反应式如下,DLVH为游离态地拉夫定。因此,歧化通过有两条路径对药物的溶出产生影响:一是歧化产生的游离碱(143μg/mL)的溶解度比甲磺酸盐(320 μg/mL)要低低;二是反应消耗了崩解剂NaCMC,影响了他的崩解功能。
RCT研究结果显示,3D腹腔镜胃癌根治术在手术时间上非劣效于2D腹腔镜胃癌根治术,能显著减少术中出血量,且3D腹腔镜对胃癌术中大出血(>200 mL)是独立保护因素[99]。另一项纳入1456例大宗胃肠肿瘤手术病例的Meta分析结果同样显示,与2D腹腔镜胃癌根治术比较,3D腹腔...
(AVCC), VEREF- = 0 V fADC10CLK = 5 MHz, ADC10SHTx = 0x0001, Conversion rate 200 ksps 2.2 V, 3 V ±8.5 ±26 µA I(VEREF+), I(VEREF-) Static input current 1.4 V ≤ VEREF+ ≤ V(AVCC), VEREF- = 0 V fADC10CLK = 5 MHZ, ADC10SHTX = 0x1000, Conversion rate 20 ksps...
(AVCC), VEREF- = 0 V fADC10CLK = 5 MHZ, ADC10SHTX = 0x1000, Conversion rate 20 ksps 2.2 V, 3 V ±1 µA C(VEREF±) Capacitance at VEREF+ or VEREF- terminal See (5) 10 µF (1) The external reference is used during ADC conversion to charge and discharge the capacitance ...