Quantitative RT-PCR showed that after challenge with grouper iridovirus (GIV), four of the 19 CC chemokine genes, EcSYCA102, EcSYCA103, EcSYCA116, and EcSYCA118, were highly induced in the spleen. The expression of these four genes could also be upregulated by LPS and poly (I:C) ...
accurate, this procedure relies heavily on reference databases of complete genomes, which often cannot be readily updated by the end user. Complete genomes are available for only a small fraction of the microbial eukaryotic species. For example, as of April 2019, the widely used NCBI RefSeq data...
As rates of molecular evolution can vary substantially among genes and species, it is currently not feasible to set a universal sequence similarity threshold that works equally well for all organisms and genes. By default, CCMetagen uses similarity thresholds pre- viously determined for fungi [49,...
single-cell amplified genomes (SAGs). Vannier et al. estimated their SAG to be 64% complete using eukaryotic core genes from CEGMA. We estimated the quality of the SAG using BUSCO 4.0 and EukCC, which assessed the completeness to be 56.2% and 59.65% with a contamination of 7.4% and 14.0...
The molecular evolution and functional divergence of lamprey programmed cell death genes Front Immunol, 10 (2019), Article e1382 Google Scholar 35 X. Li, R. Zhang, H. Zhang, et al. Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity J Biol Chem...
Genomic context of CpGs utilized inGIMiCC.A–CThe methylation level of representative CpGs fromGIMiCClibraries at functionally relevant genes.D–FEnrichment analysis testing for the odds of the DMCs of the GBM L0 (D), AST L0 (E), and all other deconvolution layers (F) being in a CpG is...
Cyclin D1 protein is aberrantly overexpressed in thyroid cancers, but mutations of the CCND1 gene are rare in these tumors. We investigated the CCND1 rs9344 (G870A) polymorphism and the expression profiles of wild-type CCND1a and shortened oncogenic isof
While sex refers to the biological differences between men and women defined by genes, sex hormones, and anatomy, gender encompasses the sociocultural roles, relations and behaviours [4]. Over the last decade, gender medicine, encompassing both sex and gender, has increasingly gained interest in ...
Genes Dev. 25, 2465–2479 (2011). Article CAS PubMed PubMed Central Google Scholar Aslakson, C. J. & Miller, F. R. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res. 52, 1399–1405 (...
First, we looked for genes whose expression pattern is consistently associated with the expression pattern of DDR2 in human tumors since these may conceivably be members of signaling pathways that a tumor could use to escape DDR2 depletion. Using two human bladder cancer datasets, CNUH33and MSKCC...