an integral membrane protein found in the inner nuclear membrane.The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane.This protein binds histone H3 tails methylated at Lys-9 sites.This protein is also recruited to sites of ...
The family of Heterochromatin protein 1 (HP1) proteins is a family of highly conserved heterochromatin-associated non-histone chromosomal proteins , which has important functions in nucleus. These functions include gene activation or repression, regulation of binding of cohesion complexes to centromere, ...
mouseWB,IP J Exp Med ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons. mouseWB Nat Commun The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction. humanWB,IHC,IF ...
Although CBX3 does not possess direct lactyltransferase activity, CBX3 binds histone acetyltransferase (HAT) EP300 to induce increased EP300 substrate specificity toward lactyl-CoA and a transcriptional shift toward an immunosuppressive cytokine profile. Targeting CBX3 inhibits tumor growth by both tumor...
yb-8154RHistone H2A.Z组蛋白H2AZ抗体 yb-15437RHSF2 binding protein热休克因子2结合蛋白抗体 yb-8041RHEATR2HEATR2蛋白抗体 yb-15417RHBLD2铁硫簇整合同源物2蛋白抗体 yb-0887RMV hemagglutinin glycoprotein麻疹病毒血凝素抗体 yb-11589RHOXC5同源盒蛋白HOXC5抗体 ...
Cbx3/HP1γ is a histone reader whose function in the immune system is not completely understood. Here, we demonstrate that in CD8+ T cells, Cbx3/HP1γ insufficiency leads to chromatin remodeling accompanied by enhanced Prf1, Gzmb and Ifng expression. In
Although tobacco smoking is a risk factor for lung adenocarcinoma (LUAD), the mechanisms by which tobacco smoking induces LUAD development remain elusive. Histone methylation levels in human bronchial epithelial cells have been reported to increase after
followed by a variable hinge region and a conserved carboxy-terminal chromoshadow domain. The chromodomain facilitates binding to histone H3 tri-methylated at Lys9, a histone "mark" closely associated with centromeric heterochromatin. The variable hinge region binds both RNA and DNA in a sequence-in...
an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites...
The family of Heterochromatin protein 1 (HP1) proteins is a family of highly conserved heterochromatin-associated non-histone chromosomal proteins , which has important functions in nucleus. These functions include gene activation or repression, regulation of binding of cohesion complexes to centromere, ...