The CBS gene regulates the expression of cystathionine beta-synthase (CBS), a key enzyme in the production of hydrogen sulfide (H2S) by conversion of homocysteine (Hcy). H2S is a gasotransmitter that protects cells against ischemic damage by exerting vasodilatory, anti-inflammatory and antioxidant ...
Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2010] [中文简述(自动翻译):] 由该基因编码的蛋白质用作同源四聚体来催化高半胱氨酸转化为胱硫醚,在转硫途径中的第一个步骤。所编码的蛋白质是变构由腺苷甲硫氨酸活化,并使用磷酸吡哆醛作为辅因子。
（１中南大学基础医学院，长沙４１００８３；２南华大学医学院） 摘要：目的 建立胱硫醚-β -合成酶（ＣＢＳ）基因过表达ＰＣ１２细胞株并进行鉴定。方法 根据ＧｅｎＢａｎｋ数据库中的ＣＢＳｃＤＮＡ序列设计合成ＣＢＳ基因引物，ＰＣＲ扩增ＣＢＳ基因，并将其克隆到慢病毒过表达载体ＧＶ３４１中，用 慢...
Loi-MoFungGraceChung-YanLuiEricSDOSPathologypyridoxine-responsive homocystinuria patient. Pathology. 2011; 43: 81-3.Kwok, J. S. et al. CBS gene mutations found in a Chinese pyridoxine-responsive homocystinuria patient. Pathology 43, 81-83 (2011)....
提供的CBS人源重组蛋白(P01)产品为带有GST标签的人源CBS全长序列重组蛋白,其对应的GeneID号为875。 产品描述 与其它公司提供的重组蛋白不同,该CBS人源全长重组蛋白(P01)产品为采用CFS的无细胞麦胚蛋白合成系统表达出来的重组蛋白,可表达出对细胞有毒性、易被蛋白酶降解的蛋白;并获得具有良好的可溶性,并有翻译后修...
Ian Gomez扮演Gene神父,一个有冷幽默感的牧师,Chip常去他的教堂。Gene神父对Chip的决心印象深刻,他们形成了一种不靠谱的友谊。Gene神父将帮助Chip将《圣经》的条规「翻译」成「适应现代社会」的东西。Tony Rock扮演Chip在办公室里最好的朋友Vince,两人经常一起闲聊,谈论各种小道消息。他们之所以有共同语言……是因为...
背景资料CBS,Cystathionine Beta-Synthase,catalyzes the first irreversible step of transsulfuration.The CBS enzyme is a homotetramer of 63-kD subunits and requires pyridoxal phosphate and heme for activity.The CBS gene,which is mapped to chromosome 21q22,contains 23 exons,ranging in size from 42 to...
accordingtocDNAsequenceofCBSgenefromGenBank.TheCBSgenewasamplifiedusingPCRandligatedintothelentiviralvectorGV341.293Tcellsweretransfectedwiththerecombi-nantvectorandtwokindsofpackagingviralvector.ViralsupernatantwascollectedandwasusedtotransfectPC12cells.Afterpuromycinscreening,PC12cellswithCBSgenetransfectionwere...
素进行优化,成功地建立了用高分辨率熔解曲线检 [] , , (): J.Circulation20121253482. 测分析 CBS 基因片段 SNP 位点的方法,为该位点 [] , , , 6ZhaoJYYangXYShiKHetal.Afunctionalvariantinthecys 大样本筛查提供基础,同时为其他基因的 HRM检 tathionine synthasegenepromotersignificantlyreducescongen β 测...
The FDA is set to decide Friday on a gene editing technique for patients with sickle cell disease. It would be the first use of CRISPR in the United States to treat a disease. CBS News' chief medical correspondent Dr. Jon LaPook has more.