Consistent with this, both CBP and p300 form a complex with BMAL1, but not CLOCK, in HEK293 and Hep3B cells [36], strongly suggesting that CBP/p300 targets BMAL1. However, recent studies have demonstrated that p300, but not CBP, forms a complex with CLOCK and BMAL1 in liver extract ...
The nuclear factor CREB activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner. The solution structure of the complex formed by the phosphorylated kinase-inducible domain (pKID) of CREB with KIX reve...
molecules Article Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3 Adam S. Vincek 1,2, Jigneshkumar Patel 1, Anbalagan Jaganathan 1,3, Antonia Green 4, Valerie Pierre-Louis 4, Vimal Arora 5, Jill Rehmann 4, Mihaly ...