The molecular mechanism of this process is, however, only poorly understood. Here we demonstrate that the b-adrenoceptor/cAMP/PKA pathway triggers apoptosis through the transcriptional induction of the pro-apoptotic BH3-only Bcl-2 family member Bim in tissues such as the thymus and the heart. ...
www.nature.com/scientificreports OPEN received: 17 June 2015 accepted: 23 December 2015 Published: 18 February 2016 SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation Masamichi Doiguchi1,*, Takeya Nakagawa1,*,Yuko Imamura1,...
b In vitro acetyltransferase activity of p300BRPHZT toward an H4-di-acetylated nucleosome. The histone and residue for which acetylation was detected by immunoblotting are shown above each panel. Color code: H2A, yellow; H2B, red; H3, blue; H4, green. Nucleosome (Nuc): un (black), ...